ACID–BASE BALANCE AND GAS EXCHANGE IN PATIENTS WITH DRUG-RESISTANT EPILEPSY DURING THE PERIOPERATIVE PERIOD: THE ROLE OF CLINICAL CHARACTERISTICS AND THERAPY
Abstract
Objective: To evaluate the impact of epilepsy duration and type of antiepileptic therapy on acid–base balance and oxygenation parameters in patients with pharmacoresistant focal epilepsy during the perioperative period.
Methods: A retrospective cohort study included 93 adult patients who underwent neurosurgical treatment for pharmacoresistant focal epilepsy between 2019 and 2024. Demographic data, intraoperative fluid therapy, acid–base balance, gas exchange, and respiratory outcomes were analyzed. Patients were stratified by epilepsy duration (≤15 years, >15 years) and therapy type (monotherapy, polytherapy).
Results: Neither epilepsy duration nor therapy type significantly affected acid–base balance or gas exchange. Patients with epilepsy duration >15 years required longer mechanical ventilation. Polytherapy was associated with a higher positive fluid balance (p=0.02). Early postoperative seizures occurred in 9.7% of patients and were linked to increased pH and HCO₃⁻ without gas exchange deterioration.
Conclusions: Epilepsy duration and type of antiepileptic therapy did not significantly influence acid–base balance or oxygenation in the early postoperative period but were related to fluid balance and ventilation duration. A personalized approach to perioperative fluid and respiratory management is recommended.
Number of Views: 11
Category of articles:
Original article
Bibliography link
Dossov M., Seitenov S., Bekenova N., Kuatbay G. Acid–Base Balance and Gas Exchange in Patients with Drug-Resistant Epilepsy During the Perioperative Period: The Role of Clinical Characteristics and Therapy // Nauka i Zdravookhranenie [Science & Healthcare]. 2025. Vol.27 (5), pp. 87-94. doi 10.34689/SH.2025.27.5.011Related publications:
GENETIC VARIANTS IN LIPID-ASSOCIATED GENES IN THE KAZAKHSTANI COHORT WITH ATHEROSCLEROSIS AND HYPERTRIGLYCERIDEMIA
CLONAL HEMATOPOIESIS WITH INDETERMINATE POTENTIAL IN TET2 AND DNMT3A AMONG KAZAKHSTANI INDIVIDUALS WITH ATHEROSCLEROTIC DISEASE
PRELIMINARY ANALYSIS AND ASSESSMENT OF THE HEALTH STATUS OF THE DESCENDANTS OF PERSONS EXPOSED TO RADIATION, LIVING IN THE BESKARAGAI DISTRICT OF THE ABAY REGION
PRELIMINARY ANALYSIS OF THE HEALTH STATUS AND RADIATION DOSES OF RESIDENTS OF THE ABAY DISTRICT OF THE ABAY REGION, WHO ARE DESCENDANTS OF PERSONS EXPOSED TO RADIATION DUE TO NUCLEAR WEAPONS TESTS
TRENDS AND DISPARITIES IN CANCER MORBIDITY IN KAZAKHSTAN: A REGIONAL AND AGE-BASED ANALYSIS FOR 2014-2024