IMPROVED RECOGNITION OF ADULT-ONSET COMMON VARIABLE IMMUNODEFICIENCY FOLLOWING A TARGETED EDUCATIONAL WORKSHOP: A CASE SERIES FROM KAZAKHSTAN
Common Variable Immunodeficiency (CVID) is the most common symptomatic Inborn Errors of Immunity in adults, characterized by hypogammaglobulinemia and impaired antibody responses. Despite its prevalence, limited clinical awareness frequently results in delayed diagnosis and preventable complications. We describe a case series of three adult patients identified shortly after a targeted educational workshop for family physicians in a low-awareness setting. All patients presented with recurrent respiratory tract infections as their initial clinical first major clinical manifestation. Complications included bronchiectasis, pleural empyema, chronic bronchitis, and, in one severe case, profound weight loss, chronic obstructive pulmonary disease, and cor pulmonale. Diagnostic delays ranged from 2 to 10 years. All patients demonstrated markedly reduced IgG, IgA, and/or IgM levels, meeting ESID diagnostic criteria. Immunoglobulin replacement therapy led to clinical stabilization and decreased infection burden. This series highlights the value of clinical education in improving CVID recognition and diagnostic delay.
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Abdushukurova G., Kadyrbayeva B., Auyelova A., Mirzabekova Zh., Oshibayeva A., Babayeva K. Improved recognition of adult-onset Common Variable Immunodeficiency following a targeted educational workshop: a case series from Kazakhstan // Nauka i Zdravookhranenie [Science & Healthcare]. 2025. Vol.27 (6), pp. 231-236. doi 10.34689/SH.2025.27.6.025Related publications:
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