АTHEROGENESIS AND INFLAMMATION
Introduction: The article presents atherosclerosis theory and modern views on the role of inflammation in atherogenesis. We reviewed national and international literature on inflammatory theory of atherosclerosis, the role of cytokines in the development of atherosclerosis, the interaction of the lipid and inflammatory theory of atherogenesis, the formation of atherosclerotic plaque. Basic research in molecular biology, immunology, genetics have greatly expanded the concept of the pathogenesis of atherosclerosis.
The aim: Сonducting a literature review on the pathogenesis of atherosclerosis.
Materials and methods: We performed a systematic literature search in the online resources. We found 300 sources, 68 of which were selected for the analysis. Key points of forming search queries for the formation of the literature review were presented to the following elements: "atherosclerosis", "inflammation", "cytokines", "atherogenesis."
Results: In the formation and destabilization of atherosclerotic plaques the main role can be attributed to inflammation markers.
Conclusions: Inflammation has been actively involved in the implementation of the immune response in atherosclerosis, in which the leading role played by intercellular interaction mediators - cytokines, such as interleukin-6 and TNF-α. However, despite the large number of studies on the blood inflammatory markers in atherosclerosis, to date there is no consensus on the nature and extent of the inflammatory response in this diseaseBibliography link
Аймагамбетова А.О. Атерогенез и воспаление. Обзор литературы / / Наука и Здравоохранение. 2016. №1. С. 24-39.
Aimagambetova A.O. Аtherogenesis and inflammation. Reviews. Nauka i Zdravookhranenie [Science & Healthcare]. 2016, 1, pp. 24-39.
Аймағамбетова А.Ө. Атерогенез және қабыну. Әдебиеттерге шолу / / Ғылым және Денсаулық сақтау. 2016. №1. Б. 24-39.