ASSOCIATION OF POLYMORPHISMS OF GENES OF IL1B (RS1143627), IL10 (RS1800896), IL17А (RS 2275913, RS8193036) WITH INFECTIOUS DISEASES INCLUDING ERYSIPELAS
The investigate of polymorphism of cytokine genes is an important in pathogenesis of many diseases and in identifying susceptibility to them. Knowledge of their role in the pathogenesis of many diseases, particularly infectious diseases are permits, on the one hand, to predict risk of disease or severity of its flow, on the other - to pick up individually specific therapy for a particular patient.
Despite the fact that to date, in the literature there are a significant number of studies that found an association between polymorphisms of cytokine genes and susceptibility to infectious diseases, the opinions of the authors about of markers of predisposition or resistance to infections, depending on the origin (viral or bacterial infection) are inconsistent.
The aim of this systematic review are analysis of publications on the association of polymorphisms of cytokine genes (rs1143627, rs1800896 rs8193036, rs 2275913) with infectious diseases, including erysipelas for identify the markers of susceptibility to infectious diseases.
Materials and methods. The study included full-text publications in English and Russian languages over the past 10 years, which was investigated genetic markers to infectious diseases on the basis of cytokine gene polymorphisms (rs1143627, rs8193036, rs 2275913, rs1800896).
Results. As a result, the search has been identified 786 sources in databases Pubmed, Scopus, e -Library. After the screening were selected and included in the study 18 full-text articles.
Conclusions. Polymorphism of IL10 gene (rs1800896) plays key role at chronic viral hepatitis C. Practicullar, GG genotype was associated with susceptibility to chronic viral hepatitis C. Allele T and TT genotype of polymorphism rs1143627 of IL1B gene are poor factors of susceptibility, development and current of infectious diseases, independent of genesis (viral or bacterial etiology).
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Бекенова Н.Б., Гржибовский А.М., Муковозова Л.А. Ассоциация полиморфизмов генов цитокинов ИЛ1В (rs1143627), ИЛ10 (rs1800896), ИЛ17А (rs 2275913, rs8193036) с инфекционными заболеваниями, в том числе и рожей / / Наука и Здравоохранение. 2016. №4. С. 104-118. Bekenova N.B., Grjibovski A.M., Mukovozova L.A. Association of polymorphisms of genes of IL1B(rs1143627), IL10 (rs1800896), IL17А (rs 2275913, rs8193036) with infectious diseases including erysipelas. Nauka i Zdravookhranenie [Science & Healthcare]. 2016, 4, pp. 104-118. Бекенова Н.Б., Гржибовский А.М., Муковозова Л.А ИЛ1В (rs1143627), ИЛ10 (rs1800896), ИЛ17А (rs 2275913, rs8193036) гендер полиморфизмдерінің жұқпалы аурулармен, оның ішінде тілме ауруымен байланысы / / Ғылым және Денсаулық сақтау. 2016. №4. Б. 104-118.Related publications:
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