THE MODERN UNDERSTANDING OF THE MOLECULAR MECHANISMS OF METFORMIN ACTION
There view deals with the analysis of the molecular
mechanism of the effect of metformin, the antidiabetic drug widely applied all
over the world. In addition to the hypoglycemic effect, metformin was
discovered to have several pleiotropic actions, particularly antitumor. The
effect of metformin on proliferation of cancer cells is related to activation
of AMP-sensitive kinase and suppression of mTOR, which plays an
important role in regulation of cellular growth. Glucose drop by metformin was
caused by its ability to suppress gluconeogenesis in liver through
signal pathway from LKB1, loss of which contributes to the formation of some
tumors. Since LKB1 is a
key regulator of glucose and lipids metabolism in Т-cells, and is
of significant importance for normal development and functioning of Т-cells.The
existing research works show that this medication has it s antiproliferative
effect in several ways including by direct impact and immune-mediated
inhibition of tumor growth. Two main mechanisms of metformin’s antitumor effect
were marked out: direct (insulin-independent) and indirect
(insulin-dependent). At present the mechanism of metformin effect on
carcinogenesis has not been completely explored. Further experiments and
large-scale clinical studies are required to identify cellular and molecular
mechanisms of metformin, which has high potential in diabetology and oncology
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Уразаев О. Н., Искакова С. С., Бекмухамбетов Е. Ж., Дворацка М., Дворацки Г. Современное представление о молекулярных механизмах действий метформина / / Наука и Здравоохранение. 2015. №2. С. 19-29. Urazayev O. N., Iskakova S. S., Bekmukhambetov Ye. Zh., Dworacka М., Dworacki G. The modern understanding of the molecular mechanisms of metformin action. Nauka i Zdravoohranenie [Science & Healthcare]. 2015, 2, pp. 19-29. Уразаев О. Н., Искакова С. С., Бекмухамбетов Е. Ж., Дворацка М., Дворацки Г. Метформин әрекет молекулалық механизмдерін қазіргі заманғы түсінік / / Ғылым және Денсаулық сақтау. 2015. №2. Б. 19-29.Related publications:
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