THE ROLE OF PARK GENES FAMILY IN PARKINSON DISEASE
Parkinson Disease (PD) is a neurodegenerative disease associated with degeneration of dopaminergic neurons in the basal ganglia. Parkinson disease is the second most common neurodegenerative disorder, after Alzheimer disease (rev. in Chai and Lim, 2013). The analysis of prevalence studies showed
that there were 5 mln PD patients in 2005, and there is expected increase to
9.3 mln by 2030 (Dorsay et al., 2005). The main clinical indicators of PD are
bradykinesia, postural instability, muscle rigidity and resting tremor, good
L-dope response and asymmetrical clinical manifestation. There are two types of
the pathology such as sporadic and familial forms of PD. 95% of all cases rare
sporadic, which means there are no causes that promote the disease development.
This review article aims to focus on PARK family of genes that are associated
with Parkinson Disease development. It describes possible underlying mechanisms
and clinical manifestations of the genetically predetermined Parkinson Disease
form. To the present, there are huge amount of genes-candidates for PD but this
review focuses on genes that showed significant association on Genome Wide
Association Studies of PD genes as well as to describe briefly the clinical
manifestations of different familial PD forms
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Bibliography link
Akanova A.A. The role of PARK genes family in Parkinson disease. Nauka i Zdravoohranenie [Science & Healthcare]. 2015, 3, pp. 29-36.
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