MODELING OF TYPE 2 DIABETES MELLITUS IS A NECESSARY FOUNDATION FOR STUDY OF MEDICINAL PRODUCTS WITH ANTIDIABETIC POTENCY
Taking into account the worldwide increasing number of patients with type 2 diabetes mellitus, the actual problem of modern pharmacology continues to be the development of antidiabetic drugs with high therapeutic activity and having a better risk-benefit profile. In this connection diabetes modeling is very important, it allows reliably detect the presence of a particular pharmacological activity or new components in the mechanism of drugs action. Models of diabetes can be obtained from various species of animals spontaneously, induced by chemical diabetogenic substances, dietary or surgical procedures, or a combination of these methods. This review presents examples of standard, enough studied models of type 2 diabetes mellitus (genetic and nongenetic) that are designed for small laboratory animals (mice, rats), with a brief description of their production and use. It is concluded that the modeling of type 2 diabetes mellitus is a necessary foundation for the pre-clinical study of anti-diabetic drugs, and the use of different models allows a reasonable extrapolation of the experimental data on people suffering from type 2 diabetes mellitus.
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1Г.Н. Чуканова, 2М. Дворацка, 1С.С. Искакова, 1Е.Ж. Курмамбаев МОДЕЛИРОВАНИЕ САХАРНОГО ДИАБЕТА 2 ТИПА ДЛЯ ИЗУЧЕНИЯ ЛЕКАРСТВЕННЫХ СРЕДСТВ С АНТИДИАБЕТИЧЕСКОЙ АКТИВНОСТЬЮ //Наука и Здравоохранение 2014.№ 4. С. 4-8 G.N.Chukanova1, M. Dworacka2, S.S. Iskakova1, 1Ye.Zh. Kurmambaev MODELING OF TYPE 2 DIABETES MELLITUS IS A NECESSARY FOUNDATION FOR STUDY OF MEDICINAL PRODUCTS WITH ANTIDIABETIC POTENCY // Nauka i Zdravookhranenie. 2014.№ 4. С. 4-8 Г.Н. Чуканова1, М. Дворацка2, С.С. Ысқақова1, Е.Ж. Кұрмамбаев1 ҚАНТ ДИАБЕТІНІҢ 2 ТИПІН МОДЕЛЬДЕУ- АНТИДИАБЕТТІК БЕЛСЕНДІЛІГІ БАР ЕМДІК ДӘРІ-ДӘРМЕКТЕРДІ ЗЕРТТЕУДЕГІ ҚАЖЕТТІЛІКТІҢ НЕГІЗІ // Ғылым және Денсаулық сақтау 2014.№ 4. С. 4-8Related publications:
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