THE INFLUENCE OF PROLONGED JAUNDICE ON INFANT’S NEURIDEVELOPMENT. REVIEW
Introduction. Nowadays publications on the frequency of prolonged jaundice in full-term are becoming published more frequently, which dictates a more detailed study of the possible long-term effects of damage to the infant’s CNS, in addition to the previous studies of bilirubin encephalopathy, kernicterus and Cerebral Palsy (CP).
Purpose: Analysis of modern literature and probable clinical variants of neurodevelopment disorders of infants who had prolonged jaundice.
Search strategy: According to the materials of this article, there were studied 28 English and Russian data from the databases PubMed, Web of science, Cochrane library, Google Scholar, e-library, ciberleninka.ru, dissercat.com. and 7 publications from other open sources des-cribing the course and outcome of prolonged neonatal jaundice. The original full-text articles describing the clinical aspects of this problem in mature infants were analyzed and reviewed over the past 25 years. Summary of reports, newspaper articles and personal messages, as well as full-text articles describing the course and outcomes of neonatal jaundice in premature infants were excluded from the analysis. In the bases used, 581 publications were found, of which only 28 articles and 7 publications from other open sources met the inclusion criteria, probably due to the rare frequency of prolonged jaundice in developed countries.
Results: The literature review covers the results of retrospective, prospective, and case-control studies of the course and outcomes of prolonged jaundice or severe hyperbilirubinemia, the Guidelines for the management of neonatal jaundice of the American Academy of Pediatrics, NICE, monographs and abstracts of the authors of neighboring countries and Kazakhstan were reviewed. The data on the outcomes of prolonged jaundice in the form of development of sensorineural hearing loss, decreased intelligence, emotional-volitional disorders, and physical and psychomotor development were found.
Conclusions: Prolonged jaundice is characteristic of middle and low-income countries. Etiological factors of prolonged jaundice have national and country characteristics. Belonging to the Asian population is a risk factor for the development of significant hyperbilirubinemia. Prolonged jaundice affects all organs and systems of the child. Maintaining the National Registry of hyperbilirubinemia and adherence to the recommendations of NICE or the American Academy of Pediatrics significantly improve the prognosis. It is necessary to teach future mothers about the first signs of the pathological course of neonatal jaundice.
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Rakisheva Zh.V., Lepesova M.M. The influence of prolonged jaundice оn infant’s neuridevelopment. Review. Nauka i Zdravookhranenie [Science & Healthcare]. 2019, (Vol.21) 3, pp. 45-53.Related publications:
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