CURRENT UNDERSTANDING OF THE EPIDEMIOLOGY AND RISK FACTORS FOR LUNG CANCER. LITERATURE REVIEW.
Introduction: Lung cancer continues to occupy a leading position in the structure of cancer morbidity and mortality worldwide. Morbidity and mortality rates vary depending on the regions and their level of socio-economic development. The incidence of lung cancer in the population has a clear correlation with smoking status.
Aim: to provide a review of literature data of recent years on epidemiology and leading risk factors for lung cancer.
Research strategy for publications included the search for literary sources on a research topic indexed in the databases of the electronic library e-Library, Pubmed, Web of Science, Scopus, Science Direct. To compile the review, we studied publications over the past 10 years, from 2010 to 2019, the original language is English. The search for publications was carried out in the databases of the electronic library Elibrary, Pubmed, Web of Science, Scopus, Science Direct. The review was based on sources containing reports on randomized and cohort studies (9), meta-analyses (8) and systematic reviews (4). The study excluded recurring publications, articles that discussed the clinic, treatment and complications of lung cancer, as well as articles about individual cases and summaries of reports. A total of 126 publications were analyzed, of which 67 articles corresponded to the research goals.
Results: in accordance with modern concepts, most researchers identify the leading role of Smoking as a risk factor in the mechanism of lung cancer carcinogenesis and note a clear relationship between the duration of smoking and the type of tobacco products with indicators of morbidity, mortality, survival and histological type of tumor. Along with smoking, risk factors may be occupational risk factors, environmental pollution with toxicants and others. Many authors note the increase in Smoking among women in recent years and predict an increase in the prevalence of cancer in them. Women are more likely to be diagnosed with adenocarcinoma and the five-year survival rate for women with lung cancer is higher than for men. Targeted efforts by state governments to control well-established risk factors will have the greatest impact on reducing the burden of lung cancer.
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Mukhambetzhan A.Zh., Urazayeva S.T., Urazayev O.N., Tussupkaliyeva K.Sh., Begalin T.B., Amanshiyeva A.A., Tashimova Zh.K., Kumar G.B., Nurmukhamedova Sh.M. Current understanding of the epidemiology and risk factors for lung cancer. Literature review // Nauka i Zdravookhranenie [Science & Healthcare]. 2020, (Vol.22) 2, pp. 27-37. doi:10.34689/SH.2020.22.2.003Related publications:
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