IMMUNOLOGICAL ASPECTS OF THE EFFECTIVENESS OF ALLERGEN-SPECIFIC IMMUNOTHERAPY. LITERATURE REVIEW.
Introduction: Seasonal allergic diseases are currently a global medical and social problem. To date, the most effective method of treating allergic diseases is allergen-specific immunotherapy. This treatment method affects all pathogenetic links of the allergic process and has a long preventive effect after completion of treatment courses.
Objective: To consider the immunological mechanisms of allergen-specific immunotherapy in patients with seasonal allergic diseases according to a literature review.
Search strategy: The search for sources was carried out in scientific databases of evidence-based medicine (PubMed, Scopus, Ebscohost, Medline, The Сochrane Library, SpringerLink, Web of Science) and in electronic scientific libraries (Google Academy, websites of medical periodicals of countries CIS, e-library.ru). Depth of search from 2008 to 2020. The database data revealed a large number of literary sources, which selected in accordance with the context of the study. Of the 119 literary sources, 102 publications selected. Inclusion criteria: as an analytical material for this article, reports on randomized and cohort studies were selected; meta-analyzes and systematic reviews; full-text and publicly available publications; Articles in Russian and English with statistically verified conclusions. The exclusion criteria were articles of low methodological quality that did not have evidence.
Results: The review analyzed the results of the most important clinical trials and various schemes of allergen-specific immunotherapy. The allergen-specific immunotherapy effect realized through the following main immunological mechanisms: initiation and maintenance of the transition from T-helper 2 to T-helper 1 immunological response, in the development of which regulatory T- cells played the main role, releasing immunosuppressive cytokines interleukin -10 and transforming growth factor, which induce production immunoglobulin G4. The basis of this process is the shift in the balance between immunoglobulin E and immunoglobulin G4 in the direction of enhancing the production of the latter, which considered a fundamentally important condition for successful allergen-specific immunotherapy and provides long-term clinical tolerance.
Conclusions: To date, allergen-specific immunotherapy is the most effective and safe method of treating seasonal allergic diseases. Successful studies in the determination of allergen-specific immunotherapy biomarkers provide great prospects for the active prevention of a wide range of allergic diseases and their complications.
Number of Views: 353
Category of articles:
Reviews
Bibliography link
Izmailovich M.R., Gazalieva M.A., Glushkova N.E., Dedova O.Yu., Mendybay S.T., Skvortsova A.V. Immunological aspects of the effectiveness of allergen-specific immunotherapy. Literature review // Nauka i Zdravookhranenie [Science & Healthcare]. 2020, (Vol.22) 2, pp. 38-48. doi:10.34689/SH.2020.22.2.004Related publications:
ANALYSIS OF ANTIBIOTIC PRESCRIBING PRACTICES IN PRIMARY HEALTH CARE SETTINGS. PART
GENETIC SUSCEPTIBILITY TO RADIATION-RELATED DISEASES: A REVIEW OF CURRENT LITERATURE
ТЕНДЕНЦИИ ЗАБОЛЕВАЕМОСТИ ИНФЕКЦИОННОГО ЭНДОКАРДИТА ПОСЛЕ ОБНОВЛЕНИЯ МЕЖДУНАРОДНЫХ РУКОВОДСТВУЮЩИХ ПРИНЦИПОВ. ОБЗОР ЛИТЕРАТУРЫ
СРАВНЕНИЕ МЕТОДОВ МОДЕЛИРОВАНИЯ РЕЦЕССИИ ДЕСНЫ НА ЛАБОРАТОРНЫХ ЖИВОТНЫХ
THE ROLE OF ESSENTIAL AND TOXIC TRACE ELEMENTS IN THE DEVELOPMENT OF KIDNEY STONE DISEASE. LITERATURE REVIEW