MODERN CONCEPTS OF THE ROLE OF INFECTIOUS AGENTS IN THE DEVELOPMENT OF CARDIOVASCULAR DISEASES. LITERATURE REVIEW.
Introduction. Cardiovascular diseases (CVD) are the leading cause of death worldwide. The main cause for the development of CVD is atherosclerosis (AS). Despite a significant reduction in traditional risk factors, the incidence of CVD remains high. This fact indicates presence of unknown factors involved in the pathogenesis of AS. Since atherosclerosis is associated with a chronic inflammatory response, the participation of viral and bacterial infections in its development has been studied. The contribution of infectious agents to the development of atherosclerosis and, accordingly, CVD is becoming more recognizable and may become a potential therapeutic target.
Purpose: to systematize and evaluate the contribution of infectious factors to the development and progression of atherosclerosis as a factor in cardiovascular catastrophes according to the literature.
Search strategy: Search for publications was conducted in the databases PubMed, The СochraneLibrary, Medscape, and GoogleScholar. The search depth was 10 years from 2010 to 2020. Inclusion criteria: reports on randomized and cohort studies conducted in large populations; meta-analyzes and systematic reviews; articles in English and Russian. Exclusion criteria: articles describing single cases and series of cases; materials published before 2010, materials that do not have evidence, summaries of reports, abstracts and newspaper articles. During the search 147 sources were found. Ninety six of them were selected and analyzed for a detailed study.
Results: An analysis was made of the connections of the infectious process and the development of atherosclerotic lesions of the vascular bed. The effect of various infectious agents on each stage of the development and destabilization of atherosclerotic plaque was determined, and the attempts at anti-infection therapy for CVD were evaluated.
Conclusions: It was summarized that infection and carriage of pathogenic microorganisms affects the development and progression of atherosclerotic complications, cardiovascular diseases. However, anti-infection therapy in CVD in clinical trials did not show positive results.
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Madieva M.I., Abilmazhinova G.D. Modern concepts of the role of infectious agents in the development of cardiovascular diseases. Literature review // Nauka i Zdravookhranenie [Science & Healthcare]. 2020, (Vol.22) 3, pp. 42-54. doi:10.34689/SH.2020.22.3.007Related publications:
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