MOLECULAR PATTERNS OF FOOD ALLERGY IN CHILDREN: REVIEW
Background: today molecular diagnosis is an innovative approach, used to characterize the molecular components of each allergen that participate in allergic process and includes specific IgE mediators (sIgE). In clinical practice, component diagnostics allows doctors to increase the accuracy of the clinical diagnosis, choose effective therapy and perform a prognosis of the disease.
Aim of the study: to analyze published data regarding the prevalence and patterns of food allergies in children of different ages.
Search strategy: Search for scientific publications in the search engines PubMed, Cochrane Library, GoogleScholar, GoogleAcademia, in the electronic scientific library eLibrary.ru, CyberLeninka. Inclusion criteria: publications of Kazakhstan authors, as well as scientific works from closest and far abroad; full-text epidemiological and clinical studies; the search depth was 10 years (2010-2020) due to the importance of revealing the sequence of specific molecular allergy diagnosis historical development. The study was carried out by next keywords searching: molecular allergy diagnosis, food allergy, major food allergens, specific IgE. Preference was given to works with a high-quality design, such as cohort studies, systematic reviews, meta-analysis. In case of absence, the results of cross-sectional studies were taken into account. Our analysis included 56 works.
Results: molecular allergological diagnosis is an important step in improving the accuracy of determination of IgE-mediated sensitization in food allergies. The ability to correctly identify and characterize individual allergens at the molecular level leads to a clear understanding of mechanisms in food sensitization.
Conclusions: New insights and trends regarding the sensitization process have been identified, new possibilities and effectiveness of specific immunotherapy using recombinant allergens have been identified.
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Vlashenyuk K.G., Morenko M.A., Zhumambayeva S.M., Rozenson R.I. Molecular patterns of food allergy in children: review // Nauka i Zdravookhranenie [Science & Healthcare]. 2020, (Vol.22) 4, pp. 49-59. doi:10.34689/SH.2020.22.4.005Related publications:
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