THE ROLE OF CYTOKINE GENE POLYMORPHISMS IN BACTERIAL INFECTIONS, INCLUDING BRUCELLOSIS. LITERATURE REVIEW
Relevance. Studies conducted to date have shown the presence of associations of gene polymorphisms of a number of cytokines with a predisposition or resistance to the development of many infectious diseases.
Aim. This review is devoted to the analysis of literature on the association of cytokine gene polymorphisms in infectious diseases of bacterial origin, in particular, with brucellosis.
Search strategy. Search of scientific publications in the search engines Pub Med, Google Scholar, Google Academia, in the electronic scientific library eLibrary.ru, CyberLeninka 10 years deep. Criteria for search information: years of search included one decade (2008-2018); publications were in Russian, Kazakh and English; full-textured epidemiological and clinical studies. Exclusion criteria: publications with animal studies, recurring publications, conference proceedings, and clinical cases.
Results. An analysis of literature showed that bacterial infections such as tuberculosis, erysipelas and brucellosis are most often associated with polymorphisms of genes of the following cytokines: TNF-α, IL-10, IL-1β, IL-17A, IL-6.The results of the analysis also showed that the same polymorphisms in different ethnic groups can be associated with both predisposition and resistance. Polymorphisms of the IL-6, IL-10, and IL-17 genes were more often associated with brucellosis.
Conclusion. Thus, such studies must be carried out in a certain population of people of the same nationality.
Number of Views: 385
Category of articles:
Reviews
Bibliography link
Mukovozova L.A., Bekenova N.B., Tokaeva A.Z., SmailYe.M. The role of cytokine gene polymorphisms in bacterial infections, including brucellosis. Literature review // Nauka i Zdravookhranenie [Science & Healthcare]. 2020, 5 (Vol.22), pp. 47-56. doi:10.34689/SH.2020.22.5.004Related publications:
ANALYSIS OF ANTIBIOTIC PRESCRIBING PRACTICES IN PRIMARY HEALTH CARE SETTINGS. PART
GENETIC SUSCEPTIBILITY TO RADIATION-RELATED DISEASES: A REVIEW OF CURRENT LITERATURE
ТЕНДЕНЦИИ ЗАБОЛЕВАЕМОСТИ ИНФЕКЦИОННОГО ЭНДОКАРДИТА ПОСЛЕ ОБНОВЛЕНИЯ МЕЖДУНАРОДНЫХ РУКОВОДСТВУЮЩИХ ПРИНЦИПОВ. ОБЗОР ЛИТЕРАТУРЫ
СРАВНЕНИЕ МЕТОДОВ МОДЕЛИРОВАНИЯ РЕЦЕССИИ ДЕСНЫ НА ЛАБОРАТОРНЫХ ЖИВОТНЫХ
THE ROLE OF ESSENTIAL AND TOXIC TRACE ELEMENTS IN THE DEVELOPMENT OF KIDNEY STONE DISEASE. LITERATURE REVIEW