MODERN CONCEPTS OF THE ROLE OF CHRONIC VIRAL HEPATITIS IN THE DEVELOPMENT OF COGNITIVE IMPAIRMENT
Introduction In recent decades, studies have shown that in chronic viral hepatitis there is a wide range of extrahepatic manifestations associated with viral replication both in the liver and outside it, which leads to damage to various organs. Cognitive dysfunction is associated with both a violation of the toxic and synthetic function of the liver, and with the replication of viruses in the central nervous system. Due to the fact that cognitive dysfunction is associated with chronic persistence of viruses, their participation in the development of these extrahepatic manifestations was studied. Analysis of the role of viral agents in the formation of impairments in cognitive functions can improve the effectiveness of diagnostic and therapeutic methods in this category of patients.
Purpose: to systematize and evaluate the development of cognitive functions in patients with chronic viral hepatitis according to modern literature.
Search strategy: The search for sources was carried out in the databases PubMed, The Сochrane Library, Scopus, elibrary. The search depth was 15 years from 2005 to 2020. Inclusion criteria: reports of randomized and cohort studies, meta-analyzes and systematic reviews; articles in English and Russian. Exclusion criteria: materials with no evidence base, newspaper articles. During the search, 86 sources were found, of which 31 sources were selected and analyzed for a more detailed study.
Results: The analysis of the relationship between the formation of cognitive impairments and the development of the infectious process in viral hepatitis was carried out. The effect of various factors in the formation of cognitive dysfunction in patients with CVH was determined, the role of antiviral therapy in CVH on the dynamics of the development of cognitive dysfunctions was assessed.
Conclusions: Development of an infectious process in CVH affects the formation and progression of cognitive impairment. However, timely conducted in clinical trials antiviral therapy for CVH showed positive results in reducing and reversing cognitive dysfunctions.
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Polukchi T.V., Slavko Ye.A., Abuova G.N. Modern concepts of the role of chronic viral hepatitis in the development of cognitive impairment // Nauka i Zdravookhranenie [Science & Healthcare]. 2021, (Vol.23) 4, pp. 58-65. doi 10.34689/SH.2021.23.4.006Related publications:
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