PROSPECTS FOR USING ENTEROSORBENTS IN PHARMACY
Introduction: A review of the literature on enterosorbents that absorb harmful and toxic substances from the human body. The classification and therapeutic effects of enterosorbents are considered. The importance of the natural enterosorbent pectin in the form of a drug and a natural product used in the daily diet is considered.
Purpose: A review of the literature on enterosorbents used in pharmaceutical practice and the importance of natural pectin enterosorbents.
Search strategy: The search for sources was carried out in the Web of Science, PubMed database (https://www.ncbi.nlm.nih.gov/pubmed/), using the specialized search engine Google Scholar and in the CyberLeninka electronic scientific library. The search depth was 15 years. The following keywords were used: MeSH Terms: enterosorbent, carbon, silicon dioxide, lignin, pectin. Inclusion criteria: publications in full-text access, meta-analyzes and systematic reviews; articles in English, Russian, research conducted on the territory of the Republic of Kazakhstan.
Exclusion criteria: articles describing single cases and series of cases; articles published earlier than 2000; materials without evidence, abstracts, abstracts and newspaper publications. A total of 4664 sources were found, of which 60 were selected for further analysis. For the final analysis, 10 articles were selected.
Results: Informational reviews of the types of enterosorbents used in pharmaceutical practice have been developed. It has been established that in the Republic of Kazakhstan there are 14 adsorption drugs in the register of registration of medicines on the pharmaceutical market. In accordance with the increase in the sorption volume of enterosorbents, it is determined that in the first place in terms of sorption capacity are preparations made on the basis of activated carbon. With long-term use of drugs based on carbon, it should be borne in mind that it is not used in case of irritation of the mucous membranes of the gastrointestinal tract and gastric ulcer. In case of gastric ulcer, the use of natural energy sorbents will be most effective. In particular, natural fibers, lignin, pectin.
Conclusions: Thus, enterosorbents, despite their very ancient use in medicine, are still relevant drugs. The use of this group of drugs has stepped far beyond the scope of gastroenterology and makes it possible to effectively provide assistance to patients with various diseases, such as disorders of lipid and carbohydrate metabolism, with acute intoxication and diarrhea.
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Amirhanova A.Sh., Zhexenbay N., Kizatova M.Zh., Iskakova G.K., Nabieva Zh.S., Omarkulova Zh.К. Prospects for using enterosorbents in Pharmacy // Nauka i Zdravookhranenie [Science & Healthcare]. 2021, (Vol.23) 4, pp. 75-87. doi 10.34689/SH.2021.23.4.008Related publications:
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