IMMUNOMARKERS OF RHEUMATOID ARTHRITIS
Relevance: Rheumatoid arthritis (RA) is one of the severe immuno-inflammatory diseases of the joints, the prevalence of which is 0.5-2% among the adult employable population. Meanwhile, RA occurs in women 2-3 times more often than in men. In the Republic of Kazakhstan, the prevalence of RA is 0.36-0.38%, and the incidence is 0.085-0.087%. It is known that disorders of the immune response underlie the pathogenesis of RA, while an important role in the occurrence and progression of the disease belongs to the lymphocytic and cytokine systems.
Objective: To carry out the systematic search and analysis of scientific information about the immunological profile of RA patients.
Search strategy and methods: This review article was accomplished within the framework of the AР08052703 project "Determination of microbiotic and genomic biomarkers of rheumatoid arthritis in the Kazakhstan population". The search for scientific publications was carried out in the databases PubMed, EMBASE, Elsiever, Medline, in the specialized search engine GoogleScholar.
Results: The pathophysiology of rheumatoid arthritis is characterized by a stable high level of pro-inflammatory (including TNF-α, IL-1, IL-6, etc.) and a reduced level of anti-inflammatory cytokines (such as IL-1ra, IL-4, IL-13, etc.) in the blood serum and adjacent to the bone part. Many sources report results in solidarity with the data above, however, there are also contradictory data regarding the concentration of individual cytokines (for instance, IL-2, IL-13, etc.).
Conclusion: The immunological profile of patients RA is currently an urgent and insufficiently studied problem, including in Kazakhstan. Considering the immunopathogenetic data, morbidity, high disability and economic damage to RA, this problem, definitely, requires special attention.
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Khochshanov Ye.Y., Ainabekova B.A., Issilbayeva A.A., Meiramova A.M., Chulenbayeva L.Y. Immunomarkers of rheumatoid arthritis // Nauka i Zdravookhranenie [Science & Healthcare]. 2022, (Vol.24) 4, pp. 146-156. doi 10.34689/SH.2022.24.4.019Related publications:
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