CLINICAL AND FUNCTIONAL STATE OF THE KIDNEYS IN PATIENTS WITH ACUTE LEUKEMIA AFTER BONE MARROW TRANSPLANTATION
Background. Bone marrow transplantation (BMT) is a fundamental therapy for high-risk resistant hematological diseases. According to world data, more than 50,000 BMT are carried out annually, and the five-year survival rate is more than 50% for many treated forms. Recent studies have shown that the prevalence of chronic kidney disease (CKD) is approximately 16.6% in BMT recipients. Bone marrow transplantation is known to be associated with several known side effects, but renal complications are not clearly defined. In developing countries, where BMT has been carried out for several decades, there are isolated studies on the complications of renal dysfunction in patients with acute leukemia after bone marrow transplantation. No such studies have been conducted in the Republic of Kazakhstan.
In this review, we have tried to focus on the most studied and known renal disorders developing after bone marrow transplantation.
Aim. To analyze the literature sources on the study of the functional state of the kidneys after bone marrow transplantation.
Search strategy.The search for scientific publications in PubMed search engines was carried out, eLibrary.ru , Google Scholar. The depth of the scientific literature search was 13 years (2009-2022). Keywords were used: bone marrow transplantation, acute leukemia, chronic kidney disease, acute renal failure, nephrotic syndrome, thrombotic microangiopathy. Russian Russian inclusion criteria were: period of 13 years (2009-2022), publications in English, age of patients over 18 years, type of articles - review article, randomized controlled trials, meta-analysis, systematic review, series of clinical cases, regulatory documents in English and Russian. Exclusion criteria: publications with unclear conclusions, recurrent publications, conference materials and descriptions of clinical cases. As a result of the search, we studied 133 foreign and domestic publications, of which 97 publications were included in this review.
Results and conclusions. Analysis of literature data has shown that kidney damage is a frequent occurrence after bone marrow transplantation. Kidney damage of various etiologies often occurs in the first 100 days after TCM. In the future, TCM recipients develop chronic kidney disease with a frequency of 7 to 48% and progress to end-stage renal failure in about 4% of patients with CKD.
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Murzakhmetova A.O., Azimbayeva I.M., Meiramova A.M., Vorobyev P.A., Ainabekova B.A. Clinical and functional state of the kidneys in patients with acute leukemia after bone marrow transplantation // Nauka i Zdravookhranenie [Science & Healthcare]. 2022, (Vol.24) 4, pp. 165-175. doi 10.34689/SH.2022.24.4.021Related publications:
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