GENETIC VARIANTS OF MEDULLOBLASTOMA IN CHILDREN AND APPROACHES TO ITS TREATMENT. LITERATURE REVIEW.
Relevance: Medulloblastoma is one of the most common malignant neoplasms of the central nervous system in childhood. The genetic characteristics of the disease may play an important role in determining treatment approaches, but this aspect has not been sufficiently studied to date.
Objective: General characteristics of current information about the genetic variants of medulloblastoma in the context of the possibility of purposeful formation of a treatment trajectory.
Search strategy: A number of original publications and reviews in the field of research for 2012-2022 were analysed, but we also included publications earlier than 2012, since they contain information about this pathology in childhood and classical basic approaches in the therapy and stratification of the disease. The selection of publications was carried out in accordance with the purpose of the review - the most complete and compact characterization of the genetics of medulloblastoma in accordance with modern treatment.
Results and Conclusions: In general, there are currently substantial grounds for the development of differentiated approaches to the treatment of MB in children based on various types of side effects on radiation and chemotherapy. However, even in world medicine, the practical use of such approaches is limited. There are currently 4 major genetic types of medulloblastoma with many subtypes, in this connection, some hypotheses have been put forward about the de-escalation of therapy. Data on the effect of genetic types on treatment are limited to single studies, and the final approved conclusions, according to the hypotheses put forward, are not reflected in the recommendation materials.
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Nussupova R.R., Pack L.A., Muldakhmetov M.S., Ibraimov B.A. Genetic variants of medulloblastoma in children and approaches to its treatment. Literature review // Nauka i Zdravookhranenie [Science & Healthcare]. 2022, (Vol.24) 5, pp. 166-178. doi 10.34689/SH.2022.24.5.021Related publications:
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