FEATURES OF GENETIC POLYMORPHISM OF NON-ALCOHOLIC FATTY LIVER DISEASE
Relevance: The global prevalence of non-alcoholic fatty liver disease (NAFLD), as well as its steady increase in recent decades, is one of the important problems of medical research. The study of genetic predisposition to the disease is one of the important tasks for early diagnosis and prevention of adverse outcomes and mortality.
Objective: To bring together current knowledge of the most studied genetic associations of NAFLD that are associated with disease susceptibility and progression.
Search strategy: Research publications (meta-analyses, cohort studies) were searched in search engines E-Library, PubMed, Google Scholar for 2010-2022. Articles of an earlier publication related to this pathology and containing the first information about the genetic aspects of NAFLD published before 2010 were also analyzed. Search keywords included "non-alcoholic fatty liver disease", "epidemoiology" "genetics" "severity of course". By sorting similar articles, over 145 publications were included in the analysis.
Results and Conclusions: This review examines the prevalence of NAFLD, its genetic predictors that affect the susceptibility and progression of the disease. Meta-analyses have identified several candidate genes that are directly correlated with the aggressive course and poor outcome of NAFLD. Further studies are needed to help in the search for strategic directions to reduce the incidence among all categories of patients with this pathology. Accordingly, the chosen direction is one of the trends in world medical research.
Number of Views: 367
Category of articles:
Reviews
Bibliography link
Alieva S.A., Nikitin I.G., Dedov E.I., Ettinger O.A., Pak L.A., Kassym L.T., Zhabagin K., Krykpayeva A.S., Makhatova A.R., Zhumatay А.B., Какытаева А.E. Features of genetic polymorphism of non-alcoholic fatty liver disease // Nauka i Zdravookhranenie [Science & Healthcare]. 2023, (Vol.25) 1, pp. 209-222. doi 10.34689/SH.2023.25.1.025Related publications:
PATHOLOGICAL CHANGES IN LUNG TISSUE UNDER THE INFLUENCE OF ELECTRONIC CIGARETTES. LITERATURE REVIEW.
BRUCELLA SPP. ANTIGENS IMPACT IN THE PATHOGENESIS AND DIAGNOSIS OF HUMAN BRUCELLOSIS
RADIATION EXPOSURE IN THE SEMIPALATINSK REGION: TRANSGENERATIONAL RISKS AND DOSIMETRY APPROACHES
TRENDS AND PATTERNS OF MALE REPRODUCTIVE SYSTEM DISEASES IN THE CONTEXT OF MEDICAL AND DEMOGRAPHIC INDICATORS. LITERATURE REVIEW
INFECTIOUS COMPLICATIONS OF UROLOGICAL INTERVENTIONS FOR UROLITHIASIS. LITERATURE REVIEW