FEATURES OF GENETIC POLYMORPHISM OF NON-ALCOHOLIC FATTY LIVER DISEASE
Relevance: The global prevalence of non-alcoholic fatty liver disease (NAFLD), as well as its steady increase in recent decades, is one of the important problems of medical research. The study of genetic predisposition to the disease is one of the important tasks for early diagnosis and prevention of adverse outcomes and mortality.
Objective: To bring together current knowledge of the most studied genetic associations of NAFLD that are associated with disease susceptibility and progression.
Search strategy: Research publications (meta-analyses, cohort studies) were searched in search engines E-Library, PubMed, Google Scholar for 2010-2022. Articles of an earlier publication related to this pathology and containing the first information about the genetic aspects of NAFLD published before 2010 were also analyzed. Search keywords included "non-alcoholic fatty liver disease", "epidemoiology" "genetics" "severity of course". By sorting similar articles, over 145 publications were included in the analysis.
Results and Conclusions: This review examines the prevalence of NAFLD, its genetic predictors that affect the susceptibility and progression of the disease. Meta-analyses have identified several candidate genes that are directly correlated with the aggressive course and poor outcome of NAFLD. Further studies are needed to help in the search for strategic directions to reduce the incidence among all categories of patients with this pathology. Accordingly, the chosen direction is one of the trends in world medical research.
Number of Views: 157
Category of articles:
Reviews
Bibliography link
Alieva S.A., Nikitin I.G., Dedov E.I., Ettinger O.A., Pak L.A., Kassym L.T., Zhabagin K., Krykpayeva A.S., Makhatova A.R., Zhumatay А.B., Какытаева А.E. Features of genetic polymorphism of non-alcoholic fatty liver disease // Nauka i Zdravookhranenie [Science & Healthcare]. 2023, (Vol.25) 1, pp. 209-222. doi 10.34689/SH.2023.25.1.025Related publications:
HEMODYNAMICALLY SIGNIFICANT PATENT DUCT ARTERIUS IN PREMATURE NEWBORN CHILDREN. LITERATURE REVIEW
RADIOIODINE-RESISTANT DIFFERENTIATED THYROID CANCER: CLINICOPATHOLOGICAL CHARACTERISTICS, MOLECULAR GENETIC ALTERATIONS. REVIEW.
INTERMITTENT BLADDER CATHETERIZATION AS THE “GOLD STANDARD” FOR THE TREATMENT OF NEUROGENIC BLADDER IN PERSONS WITH SPINAL CORD INJURY
IMPACT OF ARUBA TRIAL ON CURRENT PRACTICE: INTERVENTIONAL TREATMENT AND STROKE RATES IN UNRUPTURED BRAIN ARTERIOVENOUS MALFORMATIONS IN THE POST-ARUBA ERA
SMALL AIRWAY DISEASE IS A PREDICTOR FOR EARLY DIAGNOSTIC OF COPD