THE USE OF PHOTODYNAMIC THERAPY IN WOMEN WITH HPV-ASSOCIATED PRECANCEROUS CERVICAL DISEASE. LITERATURE REVIEW
Relevance: This article provides a brief overview of modern methods of diagnosis and treatment of cervical cancer. Special attention is paid to the etiological factor of cervical precancerous development – human papillomavirus (HPV). The role of the immune system during HPV infection and the main methods of treatment of cervical dysplasia are described. The article also discusses in detail the mechanism of action of photodynamic therapy (PDT) in the treatment of cervical dysplasia in women of childbearing age.
PDT is a high-tech treatment method that uses a combination of photosensitizer, light and molecular oxygen. The method is based on the mechanisms of free radical oxidation, violation of the vascular stroma of tumors and elimination under the action of immune cells. It is a non-invasive, effective and safe treatment that allows you to damage and destroy the structures of the affected area. However, in order to normalize the immune response, providing a stable regression of carcinogenesis, prolonged elimination of HPV is necessary. The article presents an overview of foreign and domestic articles on the safety and effectiveness of the use of PDT. The role of the immune response in HPV-associated precancerous diseases of the cervix is considered. Destructive and non-destructive methods of treatment of cervical dysplasia are described. The first sources of photodynamic therapy in gynecology, as well as the advantages and disadvantages of PDT are disclosed in this article.
Aim: to analyze the literature data on the use of photodynamic therapy in women with HPV-associated precancerous cervical disease.
Search strategy: Analysis of publications on the research topic, sources indexed in the databases of the electronic library e-Library, Google Academy, Pubmed, Web of Science, Scopus. The inclusion criteria were: reports on randomized and cohort studies conducted on large populations, meta-analyses and systematic reviews, original full-text articles in English and Russian that are publicly available and contain statistically confirmed conclusions. Exclusion criteria: summary reports, newspaper articles and personal messages. The search depth was 10 years (2013-2023). The relevant search yielded 2,200 articles, after the initial analysis, 45 articles were selected for the final analysis
Results: According to the results of our literature review, the results of studies show that the use of photodynamic therapy in women with HPV-associated precancerous cervical disease is a promising research area. Further clinical studies are needed to evaluate the effectiveness, safety and optimal timing.
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Shanazarov N.A., Kisikova S.D., Albayev R.K., Afanasyev M.S., Khamidullina Z.G., Grishacheva T.G., Khangeldi A.Yе. The use of photodynamic therapy in women with HPV-associated precancerous cervical disease. Literature review // Nauka i Zdravookhranenie [Science & Healthcare]. 2023, (Vol.25) 4, pp. 231-240. DOI 10.34689/SH.2023.25.4.028Related publications:
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