COMPARATIVE EVALUATION OF COSMETIC RESULTS OF TREATMENT IN STANDARD, ACCELERATED HYPOFRACTION AND DYNAMIC MODES OF RADIATION THERAPY OF BREAST CANCER

Background: Today evaluating the cosmetic result is an actual problem and is one of the indicators of a well-conducted organ-saving treatment. Preservation of high quality of life, achievement of good cosmetic results in patients with early breast cancer after complex treatment is an important task of modern oncology.

Aim: The aim of this study is to compare the cosmetic results of treatment with standard, accelerated hypofractionated and dynamic regimens of radiotherapy for breast cancer.

Methods: The design of the study is a non-randomized clinical trial. For the period from 2014 to 2017 years we analyzed the results of treatment of 50 patients with breast cancer who received the hypofractionated radiation therapy after surgical treatment. To assess the cosmetic effect of treatment with standard and accelerated hypofractionated radiotherapy, an objective and subjective analysis was performed. Reliability of differences in comparing cosmetic results of treatment between patients who received standard, hypofractionated and dynamic regimens of radiation therapy was performed using the Wilcoxon-Mann-Whitney method.

Results: Comparison of cosmetic results with hypofractionated and standard radiotherapy regimens showed "excellent" and "good" cosmetic results were recorded in 66% of patients with a SOD of 43.2 Gy for the remainder of the breast, whereas when SOD was administered in standard mode to 50 Gy - "Excellent" and "good" cosmetic results were recorded in 60% of patients (p = 0.049). "Excellent" and "good" results of treatment were obtained in the majority of 33 (66%) patients: in 18 (72%) patients who received GFLT, these parameters were 60% (15 people) in the standard mode.

Conclusions: Evaluation of the results of cosmetic effect depending on different regimens of RT does not demonstrate significant differences in the study groups.

Thus, the use of a new radiotherapy technique with dose hypofractionation did not impair the cosmetic results of treatment.

 

Key words: breast cancer, cosmetic result, radiation therapy, hypofraction.

Almagul S. Zhabagina, http://orcid.org/0000-0001-8956-6286

Yеvgeniya O. Kossymbayeva, http://orcid.org/0000-0003-2893-0384

Tasbolat A. Adylkhanov, http://orcid.org/0000-0002-9092-5060

Ainur S. Baissalbayeva, http://orcid.org/0000-0002-7092-7448

Kuantkan T. Zhabagin, http://orcid.org/0000-0002-4304-5132

Daniyar T. Raissov, http://orcid.org/0000-0002-3872-1263

Oncology and radiology department,

Semey State Medical University,

Semey, Kazakhstan;

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Zhabagina A.S., Kossymbayeva Yе.O., Adylkhanov T.A., Baissalbayeva A.S., Zhabagin K.T., Raissov D.T. Comparative evaluation of cosmetic results of treatment in standard, accelerated hypofraction and dynamic modes of radiation therapy of breast cancer. Nauka i Zdravookhranenie [Science & Healthcare]. 2017, 6, pp. 78-87.