REDUCTION OF CONGENITAL MALFORMATION FREQUENCY ACCORDING TO THE DATA OF GENETIC SERVICE OF PERINATAL CENTER OF SEMEY CITY FROM 2010 TO THE FIRST HALF OF 2015
Congenital malformations (CM) are heterogenic group of pathological states which include isolated, system and multiple abnormalities of organs and systems of different etiology: genetic, environmental and multifactorial [6]. CMs are serious medical and social problem that related to increase of specific weight of abnormal development in structure of perinatal child mortality and disability. Among newborns, frequency of CM defined during the first year of life reaches 5%. [8]. CM are leaders in reason structure of perinatal mortality.
The aim of research is study of statistical data of CM in regions of East Kazakhstan district attached to perinatal center of Semey for the period from 2010 to the first half of 2015.
Materials and methods: Ultrasound investigations data of pregnant women performed from 2010 to the first half of 2015 were studied. These ultrasound investigations were performed in regions of East Kazakhstan district attached to perinatal center of Semey (Semey, Kurchatov, Abay, Ayagoz, Urdzhar, Beskaragay and Boroduliha regions). Retrospective data presented by the National Genetic Register of the Republic of Kazakhstan were studied during the investigation. Statistical and analytical methods were practiced.
Structure of CM in studied region was analyzed. For this purpose, dynamic series of noted indicators were composed and calculation of IDD (intrauterine developmental defect) specific weight factors was made.
Results and discussion: In consequence of conducted work enhancement of some factors in 2015 in comparison with 2010 was detected. Frequency of EVM raised from 45 to 98%, reduction of ENM number was observed. Number of abnormalities of blood circulatory system, central nervous system and chromosomal abnormalities reduced in structure of СM factor. However, high frequency of dissemination of musculoskeletal system pathology in comparison with other CM was observed. In East Kazakhstan district high frequency of dissemination of congenital malformation of heart, vessels (16,0%), urogenital system (13,7) was registered.
Nаzira B. Mausymbayeva 1, http://orcid.org/0000-0002-9074-6302
Gulyash A. Tanysheva 1,2, http://orcid.org/0000-0002-9074-6302
Galina Y. Kuramova 2, http://orcid.org/0000-0001-9391-5944
Ylia A. Lariona 2, http://orcid.org/0000-0001-7330-613X
Gulnaz Zh. Sarkuchikova 1, http://orcid.org/0000-0001-6562-5421
Amina Zh. Namazova 1,
Aizhan O. Kenesary 1,
Makpal Z. Kurmangaliyeva 1
1 Semey state medical university, Internship and residency department on obstetrics and ginaecology, Semey, Kazakhstan,
2 Perinatal center, Semey, Kazakhstan
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Маусымбаева Н.Б., Танышева Г.А., Курамова Г.Ю., Ларионова Ю.А., Саркучикова Г.Ж., Намазова А.Ж., Кенесары А.О., Курмангалиева М.З. Снижениe частоты врожденных пороков развития по данным медико-генетической службы Перинатального центра города Семей за 2010 - по I полугодие 2015 годы / / Наука и Здравоохранение. 2016. №3. С. 103-112. Mausymbayeva N.B., Tanysheva G.A., Kuramova G.Y., Larionova Yu.A., Sarkuchikova G.Zh., Namazova A.Zh., Kenesary A.O., Kurmangaliyeva M.Z. Reduction of congenital malformation frequency according to the data of genetic service of Perinatal Center of Semey city from 2010 to the first half of 2015. Nauka i Zdravookhranenie [Science & Healthcare]. 2016, 3, pp. 103-112. Маусымбаева Н.Б., Танышева Г.А., Курамова Г.Ю., Ларионова Ю.А., Саркучикова Г.Ж., Намазова А.Ж., Кенесары А.О., Курмангалиева М.З. Семей қаласының Перинатальды орталығының медико-генетикалық көрсеткіштері бойынша 2010 жылдан 2015 жылдың і жартысы аралығында туа пайда болған ақаулардың кездесу жиілігінің төмендеуі / / Ғылым және Денсаулық сақтау. 2016. №3. Б. 103-112.Related publications:
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