Online ISSN: 3007-0244,
Print ISSN:  2410-4280
NON-MOTOR SYMPTOMS IN PARKINSON'S DISEASE USING THE EXAMPLE OF AKTOBE PATIENTS
Relevance. Non-motor manifestations in Parkinson's disease (PD) make their debut long before the manifestation of motor disorders. The prevalence of the frequency of non-motor symptoms (NMS) in PD ranges from 70 to 100% of patients. Common NMS in PD include: cognitive impairment, hyposmia, rapid eye movement (REM-rapid eye movement), sleep behavior disorder (RBD-REM sleep behavior disorder), depression, constipation and urination disorders. Timely diagnosis of NMS in PD contributes to early therapeutic correction. This article discusses NMS in Parkinson's disease in patients of the city of Aktobe. The aim of study: to investigate the frequency, structure and severity of NMS in patients at various stages of PD. Materials and methods: This study is a fragment of the dissertation work "Immunohistochemical markers of degenerative diseases of the nervous system". Study design: single-stage transverse. The study was conducted from May 2019 to June 2021. The study was approved at the meeting of the local Ethics Committee of the West Kazakhstan Medical University in Aktobe, Protocol No. 4 of May 17, 2019. The 1st part of the MDS-UPDRS scale-non-motor aspects of everyday life (nM-EDL) was used to evaluate the NMS. This part of the scale evaluates the effect of non-motor symptoms of Parkinson's disease on the daily activity of patients. The following statistical criteria were used: Shapiro-Wilka, descriptive statistics: median Me, lower and upper quartile, standard deviation. Correlation analysis was performed using Spearman's nonparametric criterion for two linear variables. Results and discussion: 1. All patients with PD have mild NMS with an average score of 7.5 on the MDS UPDRS-1 scale. 2. Of all the NMS, cognitive impairment (89.5%) and anxiety (89.5%) were more pronounced; the symptoms of dopamine regulation and urination disorders were the least pronounced - in 4.4% and 2.9% of cases, respectively. 3. The presence of a positive association of the average closeness between the MDS–UPDRS-1 scale (nM-EDL) and the duration of the disease (r=0.5, p<0.05) was established. Thus, with the progression of PD, there was an increase in the severity of NMS. Conclusion. The difficulties in diagnosing NMS in PD are due to the focus of neurologists' attention on the motor manifestations of PD. At the same time, NMS are an "invisible" part of the iceberg, requiring the primary attention of a doctor. The use of the MDS–UPDRS-1 (nM-EDL) scale by neurologists will contribute to the timely detection of NMS, appropriate therapeutic correction and dynamic monitoring of the severity of NMS.
Aigerim B. Utegenova1, https://orcid.org/0000-0001-5830-9703 Aigul P. Yermagambetova1, https://orcid.org/0000-0002-3230-0433 Gulnar B. Kabdrakhmanova1, https://orcid.org/0000-0001-6828-6437 Alima A. Khamidulla 1, https://orcid.org/0000-0002-5007-8151 Zhanilsin U. Urasheva1, https://orcid.org/0000-0003-0041-9218 1 West Kazakhstan Medical University named after Marat Ospanov, Department of neurology, Aktobe city, Republic of Kazakhstan.
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Utegenova A.B., Yermagambetova A.P., Kabdrakhmanova G.B., Khamidulla A.A., Urasheva Zh.U. Non-Motor Symptoms in Parkinson's Disease using the example of Aktobe patients // Nauka i Zdravookhranenie [Science & Healthcare]. 2024, (Vol.26) 1, pp. 38-45. doi 10.34689/SH.2024.26.1.005

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