COMPARATIVE EVALUATION OF THE QUALITY OF LIFE IN TRADITIONAL AND PREVENTIVE RADIOTHERAPY FOR CANCER OF THE CERVIX. PRELIMINARY CLINICAL RESULTS.
Background: Cervical cancer is one of the most common diseases of the female reproductive system. The annual increase in morbidity and mortality rates from this type of malignant neoplasm makes the problem of cervical cancer topical both in the whole world and in the Republic of Kazakhstan. The low survival rate for cervical cancer requires a detailed study of prevalence, epidemiology and mortality, which have different meanings both between countries and within the regions within the same country.
Goal: This study is a comparative assessment of quality of life in the traditional and prophylactic modes of radiation therapy for cervical cancer.
Methods: Study design is a non-randomized clinical trial. For the period from 2017 to 2018 y. we surveyed 30 patients with cervical cancer. To compare the indicators of quality of life, the Mann-Whitney U-criterion was used between the groups that received treatment according to the standard scheme (TLT) and the prophylactic irradiation of para-aortic lymph nodes in combination with traditional chemo-radiotherapy( PLT). With a p- value less than 0.05, the difference is considered statistically significant. The entire analysis was performed using SPSS ver.20 software.
Results: When considering differences in the groups with TLT and PLT in patients with cervical cancer, we found a statistically significant difference when comparing the use of different RT regimens, in the scales - physical functioning, emotional functioning, pain, loss of appetite, symptoms, sexual anxiety. The emotional state of the respondents who received treatment was 82.0 (13.1) in the TLT group, and 89.3 (23.5) - with PLT (p = 0.04). Comparative evaluation of functional scale indicators revealed that the studied patients had low levels of role-playing (88.2 points), physical (63.2 points) functioning.
Conclusions: Evaluation of the results of cosmetic effect depending on different regimens of RT does not demonstrate significant differences in the study groups. Epidemiological analysis demonstrates differences in the prevalence of cervical cancer, depending on the stage of the process, regional or urban identity, as well as different age groups of the population.
Almagul S. Zhabagina 1,
Tasbolat A. Adylkhanov 1,
Kuantkan T. Zhabagin 1,
Olga B. Andreyeva 1,
Kasym Z. Kanapiyanov 2,
Gulnaz K. Kumarova 1
1 Depertment Clinical and Radiation Oncology, Semey State Medical University;
2 Center of Nuclear Medicine and Oncology of Semey; Semey, Republic of Kazakhstan
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10. Curado M.P., Voti L., Sortino-Rachou A.M. Cancer registration data and quality indicators in low and middle income countries: their interpretation and potential use for the improvement of cancer care. Cancer Causes Control. 2009. Vol. 20, № 5. P. 751-6.
11. Demetri G.D., Kris M., Wade J. et al. Quality-of-life benefit in chemotherapy patients treated with epoetin alfa is indipendent of disease response or tumor type: results from a prospective community oncology study. Procrit. Study Group.J.Clin.Oncol.1998.Vol.16,№10.P.3412-3425.
12 Groenvold M., Klee M.C., Sprangers M. A., Aaronson N. K. Validation of the EORTC QLQ-C30 quality of life questionnaire through combined qualitative and quantitative assessment of patient-observer agreement. J Clin Epidemiol. 1997. Vol. 50, № 4. P. 441-50.
13. Li C Quality of life in long-term survivors of cervical cancer. Maturitas.1999.Vol.32,№2.P.63-74
14.Kaufmann A., Schmidt H., Ostheimer C., Ullrich J., Landenberger M., Vordermark D. Quality of life in very elderly radiotherapy patients: a prospective pilot study using the EORTC QLQ-ELD14 module. Support Care Cancer. – 2015. Vol. 23, № 7. P. 1883-92.
15. Mackworth N., Fobair P., Prados M. D. Quality of life self-reports from 200 brain tumor patients: comparisons with Karnofsky performance scores. J Neurooncol. 1992. Vol. 14, № 3. P. 243-53
16. Roberts S.A., Hendry J.H., Swindell R. et al. Compensation for changes in dose- rate in radical low-dose-rate brachytherapy: a radiobiological analysis of a randomised clinical trial. Radiother.Oncol. 2004. Vol 70, №1. P.63-74.
17. Spilker B. Standardisation of quality of life trials: an industry perspective. Pharmacoeconomics. 1992. Vol. 1, № 2. P. 73-5.
18. Spilker B., Molinek F.R., Jr., Johnston K.A., Simpson R.L., Jr., Tilson H.H. Quality of life bibliography and indexes. Med Care. 1990. Vol. 28, № 12 Suppl. P. 1-77.
19. Steginga S.K., Dunn J. Women,s experiences following treatment of gynecologic cancer. Oncol.Nurs.Forum. 1997. Vol.24. P.1403.
20. Van Dijck S., Nelissen P., Verbelen H., Tjalma W., Gebruers N. The effects of physical self-management on quality of life in breast cancer patients: A systematic review. Breast. 2016. Vol. 28. P. 20-8.
21 Versmessen H., Vinh-Hung V., Van Parijs H., Miedema G., Voordeckers M., Adriaenssens N., Storme G., De Ridder M. Health-related quality of life in survivors of stage I-II breast cancer: randomized trial of post-operative conventional radiotherapy and hypofractionated tomotherapy. BMC Cancer. 2012. Vol. 12. P. 495.
22. Weitzner M. A., Meyers C. A. Cognitive functioning and quality of life in malignant glioma patients: a review of the literature. Psychooncology. 1997. Vol. 6, № 3. P. 169-77.
23. Weitzner M. A., Meyers C. A., Steinbruecker S., Saleeba A. K., Sandifer S. D. Developing a care giver quality-of-life instrument. Preliminary steps. Cancer Pract. 1997. Vol. 5, № 1. P. 25-31.
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Жабагина А.С., Адылханов Т.А., Жабагин К.Т., Андреева О.Б., Канапиянов К.З., Кумарова Г.К. Сравнительная оценка качества жизни при традиционной и профилактической лучевой терапии при раке шейки матки. Предварительные клинические результаты // Наука и Здравоохранение. 2018. 5 (Т.20). С. 80-87. Zhabagina A.S., Adylkhanov T.A., Zhabagin K.T., Andreyeva O.B., Kanapiyanov K.Z., Kumarova G.K. Comparative evaluation of the quality of life in traditional and preventive radiotherapy for cancer of the cervix. Preliminary clinical results. Nauka i Zdravookhranenie [Science & Healthcare]. 2018, (Vol.20) 5, pp. 80-87. Жабагина А.С., Адылханов Т.А., Жабагин К.Т., Андреева О.Б., Канапиянов К.З., Кумарова Г.К. Жатыр мойының қатерлі ісігі үшін дәстүрлі және алдын-ала сәулелік терапиясында өмір сүру сапасын салыстырмалы бағалау. Негізгі клиникалық нәтижелер // Ғылым және Денсаулық сақтау. 2018. 5 (Т.20). Б. 80-87.Related publications:
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