FREQUENCY OF OCCURRENCE OF THYROID CANCER IN THE EAST KAZAKHSTAN REGION
The paper studies oncological indicators of thyroid cancer in the population of the East Kazakhstan region during the 5-year observation period (2011-2015y). The territory of Kazakhstan, especially the regions of the East Kazakhstan region adjacent to the former Semipalatinsk nuclear test site is unfavorable with respect to the radiation background and iodine supply, which undoubtedly affected the growth of cancer diseases, including thyroid cancer
Purpose of the study. To study was the study of the epidemiological indicators of thyroid cancer in the population of East Kazakhstan region for the period from 2011 to 2015.
Materials and methods of the research. We conducted transverse epidemiological study. The database of the territorial cancer registry was used, which was created on the basis of the primary documents of the East Kazakhstan Regional Oncology Center and the regional Oncology Center of Semey (Semipalatinsk). The analysis included all registered cases of thyroid cancer for the period from 2011 to 2015. We analyzed the frequency of detection of malignant tumors of the thyroid gland. Statistical analysis and processing data have been implemented with Excel and SPSS.20. The methods of descriptive statistics are used: the central tendency (average) and its dispersion (for standardization) for the quantitative data, absolute moments and their percentages for qualitative data.
Results. The above information shows that over the five-year period 2011-2015, rates of thyroid cancer tend to increase. Analysis of morbidity rates for 5 years revealed the dynamics of the incidence of thyroid cancer in the East Kazakhstan region 2.9% 00 in 2011. up to 4.2% 00 in 2015. The incidence of thyroid cancer in the East Kazakhstan region was observed in persons aged 50 years (54 ± 10 years), and in women 12 times more often than men.
Conclusion. According to the data given, in the whole in the East Kazakhstan region an increase in the number of the continent of patients with malignant tumors of the thyroid gland is noted.
Mayra Zh. Еspenbetova 1,
Аinur S. Кrykpayeva 1,
Zhanar M. Zhumanbaeva 1,
Natalia Е. Glushkova 1,
Аsyl S. Аbenova 1, Аliya S. Serikcan 2, Zhandos М. Маgzumov 3
1 Semey State Medical University,
2 Regional Oncology Dispensary of Semey, Semey city, Republic of Kazakhstan
3 Oncology Centre of East-Kazakhstan region, Ust-Kamenogorsk city, Republic of Kazakhstan.
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13. Curado M.P., Edwards B., Shinetal H.R. Cancer Incidence in Five Continents. IARC Scientiic Publications. 2007, 9(160), pp. 896.
14. Davies L., Welch H.G. Current thyroid cancer trends in the United States. JAMA Otolaryngol Head Neck Surg. 2014, 140, pp. 317–322.
15. Espenbetova M., Zamanbekova Zh., Sadykova Sh. et al. Thyroid disorders in population living around the Semipalatinsk Nuclear Test Site, Kazakhstan. Eur J Public Health. 2015, 25(suppl 3), pp. 319-320.
16. Guth S., Theune U., Aberle J. et al. Very high prevalence of thyroid nodules detected by high frequency (13 MHz) ultrasound examination. Eur J Clin Invest. 2009, 39, pp. 699–706.
17. Hegedus L. Clinical practice. The thyroid nodule. N Engl J Med. 2004, 351, pp. 1764–1771.
18. Kilfoy B.A., Zheng T., Holford T.R. et al. International patterns and trends in thyroid cancer incidence, 1973–2002. Cancer Causes and Control. 2009, 20(50), pp. 525-531.
19. Landa I., Robledo M. Association studies in thyroid cancer susceptibility: are we on the right track? J Mol Endocrinol. 2011, 47(1), pp. R43-R58.
20. Leenhardt L., Bernier M.O., Boin-Pineau M.H. et al. Advances in diagnostic practices affect thyroid cancer incidence in France. Eur J Endocrinol. 2004, 150, pp. 133–139.
21. Mettler Jr. F.A., Bhargavan M., Homadsen B.R.. et al. Nuclear Medicine Exposure in the United States, 2005–2007. J Cancer Epidemiol. 2008, 38(5), pp.384–391.
22. Nagataki S., Nystrom E. Epidemiology and primary prevention of thyroid cancer. Thyroid. 2002, 12(10), pp. 889–896.
23. Pal T., Vogl F.D., Chappuis P.O., et al. Increased risk for nonmedullary thyroid cancer in the first degree relatives of prevalent cases of nonmedullary thyroid cancer: a hospital-based study. J Clin Endocrinol Met. 2001, 86(11), pp. 5307-5312.
24. Sherman S.I. Thyroid cancer. Lancet. 2003, 361, pp. 501-511.
25. Siegel R., Ma J., Zou Z. et al. Cancer statistics, 2014. CA Cancer J. Clin. 2014, 64, pp. 9–
26. Torre L.A., Goding A.M., Chen M.S. et al. Cancer statistics for Asian Americans, Native Hawaiians, and Pacific Islanders, 2016: Converging incidence in males and females. CA Cancer J Clin. 2016, 66(3), pp. 182-202.
27. Zhumadilov Z., Gusev B.I., Takada J. et al. Thyroid abnormality trend over time in northeastern regions of Kazakstan, adjacent to the Semipalatinsk nuclear test site: a case review of pathological findings for 7271 patients. J Rad Res. 2000, 41(1), pp. 35-44.
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Еспенбетова М.Ж., Крыкпаева А.С., Жуманбаева Ж.М., Глушкова Н.Е., Абенова А.С., Сериккан А.С., Магзумов Ж.М. Онкологические показатели рака щитовидной железы по Восточно-Казахстанской области // Наука и Здравоохранение. 2018. 5 (Т.20). С. 88-95. Еспенбетова М.Ж., Крыкпаева А.С., Жуманбаева Ж.М., Глушкова Н.Е., Абенова А.С., Сериккан А.С., Магзумов Ж.М. Frequency of occurrence of thyroid cancer in the East Kazakhstan region. Nauka i Zdravookhranenie [Science & Healthcare]. 2018, (Vol.20) 5, pp. 88-95. Еспенбетова М.Ж., Крыкпаева А.С., Жуманбаева Ж.М., Глушкова Н.Е., Абенова А.С., Сериккан А.С., Магзумов Ж.М. Шығыс Қазақстан облысы бойынша қалқанша безі обырының онкологиялық көрсеткіштері // Ғылым және Денсаулық сақтау. 2018. 5 (Т.20). Б. 88-95.Related publications:
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