SURVIVAL ANALYSIS FOR CERVICAL CANCER IN THE EAST KAZAKHSTAN REGION
Introduction. Cervical cancer (CC) is the fourth most common malignant neoplasm in women and seventh overall globally. The prognosis of the disease is affected by the stage of the disease, the condition of the lymph nodes, the depth and volume of the tumor. Five-year survival in case of unaffected lymph nodes by a tumor it can be 88-99%, in case of metastases in the lymph nodes of the pelvis it can be 50-74%.
Objective. The objective of the study was to analyze the survival rate for cervical cancer in the East Kazakhstan region.
Materials and Methods. Data from the Semey Regional Cancer Center (ROD Semey) and the regional oncology center of Ust-Kamenogorask (OOD-Ust-Kamenogorsk) were used. The study included all deaths from cervical cancer (337 cases) for the period from 2011 to 2016. Survival analysis was performed using the Kaplan-Meier method. A comparison was made between treatments.
Results. Radiation therapy was performed at 50,7% (n=171) of patients, chemotherapy was performed at 8,6% (n=29) of women, symptomatic therapy was performed at 35,6% (n=120) of patients, surgical treatment was performed at 4, 5% (n=15), conization was carried out at 0,6% (n=2). The mean survival time for surgical treatment was 29,7 (95%CI:15,4-43,9) months, for radiotherapy it was 25,0 (95%CI:21,5-28,6) months, for conization it was 18,5 (95%CI:0,0-116,3) months, for chemotherapy 12,4 (95%CI:9,9-14,8) months, for symptomatic therapy 8,8 (95%CI:6,4-11,2) months. Survival curves for all types of treatment were significantly different, the highest frequency of events were at patients who have received symptomatic treatment.
Conclusion. In summary, the longest time free from the outcome was at the surgical treatment, the prognosis was worse at patients who received symptomatic therapy.
Gulnar M. Shalgumbayeva 1,
Nurbike S. Zgotava 1,
Raida I. Faizova 1,
Amina M. Khismetova 1,
Kuralai Sh. Amrenova 1,
Ainagul M. Dosbaeva 1,
Anton O. Yurkovsky 2,
1 Department of personalized medicine
Semey State Medical University, Semey, Republic of Kazakhstan
2 Novosibirsk State Medical University, first-year student, medical faculty,
Novosibirsk, Russian Federation
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8. Jinyao Wang, Zhiqiang Bai, Zhenkun Wang and Chuanhua Yu. Comparison of secular trends in cervical cancer mortality in China and the United States: an age-period-cohort analysis // Int. J. Environ. Res. Public Health 2016, 13, 1148; doi:10.3390/ijerph13111148 www.mdpi.com/journal/ijerph
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13. Parkhurst J.O., Vulimiri M. Cervical cancer and the global health agenda: insights from multiple policy-analysis frameworks // Glob Public Health. 2013; 8(10):1093–108.
14. Rose P.G., Ali S., Whitney C.W., Lanciano R., Stehman F.B. Outcome of stage IVA cervical cancer patients with disease limited to the pelvis in the era of chemoradiation: a Gynecologic Oncology Group study. // Gynecol Oncol. 2011;121(3):542–5. doi:10.1016/j.ygyno.2011.02.024
15. Siegel R.L., Miller K.D., Jemal A. Cancer statistics, 2015 // CA Cancer J Clin 2015;65:5-29. PUBMED | CROdptmejSSREF
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17. Wright Jason D. et al. Influence of treatment center and hospital volume on survival for locally advanced cervical cancer // Gynecol Oncol. 2015 December; 139(3): 506–512. doi:10.1016/j.ygyno.2015.07.015.
18. Wright Jason D. et al. Population-Level Trends in Relative Survival for Cervical Cancer. //Am J Obstet Gynecol. 2015; November;213(5):670.e1–670.e7. doi:10.1016/j.ajog.2015.07.012
References:
1. Sharashova E.E., Kholmatova K.K., Gorbatova M.A., Grjibovski A.M. Primenenie analiza vyzhivaemosti v zdravoohranenii s ispol'zovaniem paketa statisticheskih programm SPSS [Survival analysis in health sciences using SPSS software]. Nauka i Zdravookhranenie [Science & Healthcare]. 2017, 5, pp. 5-28.
2. Aamod Dhoj Shrestha et al. Cervical Cancer Prevalence, Incidence and Mortality in Low and Middle Income Countries: A Systematic Review. Asian Pacific Journal of Cancer Prevention, Vol 19. DOI:10.22034/APJCP.2018.19.2.319
3. Cervical cancer [Internet]. [cited 2015 Aug 12]. Available from: http://www.paho.org/hq/index.php
4. Chen T., Jansen L., Gondos A., et al. Survival of cervical cancer patients in 3 Germany in the early 21st century: a period analysis by age, histology, and stage. Acta Oncol. 2012; 51:915–21. [PubMed: 22928692]
5. Eun-Kyeong Moon et all. Trends and age-period-cohort effects on the incidence and mortality rate of cervical cancer in Korea. Cancer Res Treat. 2017;49(2):526-533
6. GLOBOCAN cancer fact sheets: cervical cancer [Internet]. [cited 2015 Aug 12]. Available from: http:// globocan.iarc.fr/old/FactSheets/cancers/cervix-new.asp
7. Green J.A., Kirwan J.M., Tierney J.F., Symonds P., Fresco L., Collingwood M., Williams C.J. Survival and recurrence after concomitant chemotherapy and radiotherapy for cancer of the uterine cervix: a systematic review and metaanalysis. Lancet. 2001;358(9284):781–6.
8. Jinyao Wang, Zhiqiang Bai, Zhenkun Wang and Chuanhua Yu. Comparison of secular trends in cervical cancer mortality in China and the United States: an age-period-cohort analysis. Int. J. Environ. Res. Public Health 2016, 13, 1148; doi:10.3390/ijerph13111148 www.mdpi.com/journal/ijerph
9. Kachuri L., De P., Ellison L.F., Semenciw R. Cancer incidence, mortality and survival trends in Canada, 1970–2007. Chronic Dis Inj Can. 2013; 33:69–80. [PubMed: 23470172]
10. Levinson K.L., Bristow R.E., Donohue P.K., Kanarek N.F., Trimble C.L. Impact of payer status on treatment of cervical cancer at a tertiary referral center. Gynecologic oncology. 2011; 122(2):324–7. PubMed Central PMCID: PMCPMC4612589. doi: 10.1016/j.ygyno.2011.04.038 PMID: 21620446
11. Network N.C.C. Cervical Cancer [https://www.nccn.org/professionals/ physician_gls/pdf /cervical.pdf]. Accessed 9 Aug 2017
12. Obrzut B. et al. Prediction of 5–year overall survival in cervical cancer patients treated with radical hysterectomy using computational intelligence methods. BMC. Cancer. (2017) 17:840. doi: 10.1186/s12885-017-3806-3
13. Parkhurst J.O., Vulimiri M. Cervical cancer and the global health agenda: insights from multiple policy-analysis frameworks. Glob Public Health. 2013; 8(10):1093–108.
14. Rose P.G., Ali S., Whitney C.W., Lanciano R., Stehman F.B. Outcome of stage IVA cervical cancer patients with disease limited to the pelvis in the era of chemoradiation: a Gynecologic Oncology Group study. Gynecol Oncol. 2011; 121(3): 542–5. doi:10.1016/j.ygyno.2011.02.024
15. Siegel R.L., Miller K.D., Jemal A. Cancer statistics, 2015. CA Cancer J Clin 2015;65:5-29. PUBMED | CROdptmejSSREF
16. Torre L.A., Bray F., Siegel R.L., Ferlay J., Lortet-Tieulent J, Jemal A. Global cancerstatistics, 2012. CA: Cancer J Clin. 2015;65(2):87–108.
17. Wright Jason D. et al. Influence of treatment center and hospital volume on survival for locally advanced cervical cancer. Gynecol Oncol. 2015 December ; 139(3): 506–512. doi:10.1016/j.ygyno.2015.07.015.
18. Wright Jason D. et al. Population-Level Trends in Relative Survival for Cervical Cancer. Am J Obstet Gynecol. 2015; November; 213(5): 670.e1–670.e7. doi:10.1016/j.ajog.2015.07.012
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Шалгумбаева Г.М., Зготова Н.С., Фаизова Р.И., Хисметова А.М., Амренова К.Ш., Досбаева А.М., Юрковский А.О. Анализ выживаемости при раке шейки матки в Восточно-Казахстанской области // Наука и Здравоохранение. 2018. 5 (Т.20). С. 68-73. Shalgumbayeva G.M., Zgotava N.S., Faizova R.I., Khismetova A.M., Amrenova K.Sh., Dosbaeva A.M., Yurkovsky A.O. Survival analysis for cervical cancer in the East Kazakhstan region. Nauka i Zdravookhranenie [Science & Healthcare]. 2018, (Vol.20) 5, pp. 68-73. Шалгумбаева Г.М., Зготова Н.С., Фаизова Р.И., Хисметова А.М., Амренова К.Ш., Досбаева А.М., Юрковский А.О. Шығыс Қазақстан облысындағы жатыр мойнының қатерлі ісігі кезіндегі өміршеңдікке талдау // Ғылым және Денсаулық сақтау. 2018. 5 (Т.20). Б. 68-73.Related publications:
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