Online ISSN: 3007-0244,
Print ISSN:  2410-4280
MODERN PROBLEMS OF WORKING OUT OF NEW MEDICAL PRODUCTS
In article problems which developers of new medical products face are formulated and shown. They can be broken into three directions conditionally: economic efficiency - technology - a science. The successful decision all three directions of problems will allow to promote considerably in working out of new highly effective medicines.
R.A. Islamov, A.A. Azembayev RSE "Scientific Center for Anti-infectious Drugs", Almaty
1. Drug discovery handbook. Ed. by Sh.C. Gad. New Jersey: John Wiley&Sons, 2005. 1471p 2. LaMattina J.L. The impact of mergers on pharma-ceutical R&D // Nature Reviews Drug Discovery. 2010. Vol. 10. P.559-560 3. Paul S.M. et al. How to improve R&D productivity: the pharmaceutical industry's grand challenge // Nature Rev. Drug Discov. 2010. Vol. 9. P.203–214 4. Goodyear M. Learning from the TGN1412 trial // BMJ. 2006. Vol. 332. P. 677-678 5. DiMasi J.A., Hansen R.W., Grabowski H.G. The price of innovation: new estimates of drug development costs // Journal of Health Economics. 2003. Vol. 22. P.151–185 6. Early drug development. Ed. By M.N. Cayen New Jersey: John Wiley & Sons, 2010. 630p 7. DiMasi J.A., Grabowski H.G. The cost of biophar-maceutical r&d: is biotech different? // Manage. Decis. Econ. 2007. Vol. 28. P.469–479 8. Hopkins A.L. Network pharmacology: the next para-digm in drug discovery // Nat. Chem. Biol. 2008. Vol.4. No.11. P.682-690 9. Chang R.L., Xie L., Xie L., Bourne Ph.E., Palsson B.O. Drug off-target effects predicted using structural analysis in the context to metabolic network model // PLoS Computational Biology. 2010. Vol. 6. No. 9. e1000938 10. Marshall G.R. Limiting assumptions in structure-based design: binding entropy // J. Comput. Aided. Mol. Des. 2012. Vol. 26. P.3-8 11. Chang Ch. A., Chen W., Gilson M.K. Ligand config-urational entropy and protein binding // PNAS. 2007. Vol. 104. No. 5. P.1534-1539 12. Shuman C.F., Hämäläinen M.D., Danielson U.H. Kinetic and thermodynamic characterization of HIV-1 prote-ase inhibitors // J. of Molecular Recognition. 2004. Vol. 17. No. 2. P.106-119 13. Сарвилина И.В., Каркищенко В.Н., Горшкова Ю.В. Междисциплинарные исследования в медицине. М.: Техносфера, 2007. 368с. 14. Rauch P.J., Chudnovskiy A., Robbins C.S. et al. In-nate response activator b cells protect against microbial sepsis // Science, 2012. DOI:10.1126/science.1215173 15. Kumarasamy K.K., Toleman M.A., Walsh T.R. et al Emergence of a new antibiotic resistance mechanism in India, Pakistan, and the UK: a molecular, biological, and epidemiological study // The Lancet Infectious Diseases. 2010. Vol. 10. No. 9. P. 597-602 16. Principles of laboratory animal science. Eds. L.F. Van Zutphen, V. Baumans, A.C. Beynen. Elsevier, 2001. 416p. 17. Scheer N., Kapelyukh Y., McEwan J., Beuger V., Stanley L.A., Rode A., Wolf C.R. Modeling human cyto-chrome p450 2d6 metabolism and drug-drug interaction by a novel panel of knockout and humanized mouse lines // Mol. Pharmacol. 2012. Vol. 81. No. 1. P.63-72
Number of Views: 252

Key words:


Bibliography link

Р.А. Исламов, А.А. Азембаев СОВРЕМЕННЫЕ ПРОБЛЕМЫ РАЗРАБОТКИ НОВЫХ ЛЕКАРСТВЕННЫХ СРЕДСТВ //Наука и Здравоохранение 2012.№ 1. С. 5-6 R.A. Islamov A.A. Azembayev MODERN PROBLEMS OF WORKING OUT OF NEW MEDICAL PRODUCTS // Nauka i Zdravookhranenie. 2012.№ 1. С. 5-6 Р.А. Исламов, А.А. Азембаев ҚАЗІРГІ ЗАМАНҒЫ ЖАҢА ДӘРІЛІК ЗАТТАРДЫ ӨҢДЕУДЕГІ МӘСЕЛЕЛЕРДІ ШЕШУ // Ғылым және Денсаулық сақтау 2012.№ 1. С. 5-6

Авторизируйтесь для отправки комментариев