A CLINICAL CASE OF CYTOMEGALOVIRUS INFECTION
Relevance: Cytomegalovirus infection (CMVI) is a widespread human infection with a diverse transmission mechanism. Cytomegalovirus is most common cause of congenital infections. Frequency of congenital CMVI among newborns is about 1% in the world. The variety of clinical manifestations of the disease is due to ability of virus to infect almost all cells of the body Case from practice indicate possibility of severe liver damage and death in children with congenital cytomegalovirus infection.
On average, 90-95% of the adult population detect antibodies to CMV. The wide prevalence of this infection among the population, and the fact that CMV is the most common cause among congenital and perinatal viral infections, and lack of reliable curative and preventive means, strongly emphasize relevance of studying this problem.
Objective: On example of clinical case, familiarize with the clinical manifestations and changes in laboratory indicators, and the possible outcome of viral hepatitis caused by cytomegalovirus infection.
Materials and methods: Study design - A retrospective analysis. This clinical case is described on the basis of 3 case histories and an autopsy report of one patient.
Results: The description of this clinical case shows characteristic changes in clinical and laboratory indicators, in 5 months old girl with congenital CMV, generalized form.
Conclusions: Congenital cytomegalovirus infection in young children, along with other viral hepatitis, can cause liver cirrhosis with the formation of lethal outcome. Treatment of such cases is extremely difficult and prognosis is unfavorable. Formation of biliary cirrhosis, leading to death, as a rule, in the second half of the first year of life.
Imdat M. Efendiyev1, https://orcid.org/0000-0002-9707-1731
Anargul А. Mansurova1, https://orcid.org/0000-0003-0017-2921
Bakytzhan Danabekov1
1 NJSC "Semey Medical University", Semey c., Republic of Kazakhstan.
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Efendiyev I.M., Mansurova A.А., Danabekov B. A clinical case of cytomegalovirus infection // Nauka i Zdravookhranenie [Science & Healthcare]. 2021, (Vol.23) 3, pp. 170-175. doi 10.34689/SH.2021.23.3.019Related publications:
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