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THE MODERN UNDERSTANDING OF THE MOLECULAR MECHANISMS OF METFORMIN ACTION
There view deals with the analysis of the molecular
mechanism of the effect of metformin, the antidiabetic drug widely applied all
over the world. In addition to the hypoglycemic effect, metformin was
discovered to have several pleiotropic actions, particularly antitumor. The
effect of metformin on proliferation of cancer cells is related to activation
of AMP-sensitive kinase and suppression of mTOR, which plays an
important role in regulation of cellular growth. Glucose drop by metformin was
caused by its ability to suppress gluconeogenesis in liver t... More
mechanism of the effect of metformin, the antidiabetic drug widely applied all
over the world. In addition to the hypoglycemic effect, metformin was
discovered to have several pleiotropic actions, particularly antitumor. The
effect of metformin on proliferation of cancer cells is related to activation
of AMP-sensitive kinase and suppression of mTOR, which plays an
important role in regulation of cellular growth. Glucose drop by metformin was
caused by its ability to suppress gluconeogenesis in liver t... More
2015 year | Issue: 2 | Pages: 19-29
CROSS-SECTIONAL STUDIES IN HEALTH SCIENCES
In this paper we present basic principles of planning and carrying out cross-sectional studies in health sciences as well as analyzing the data collected in these studies. We present practical examples of sample size and effect measures calculation for cross-sectional studies using online calculators and Epi Info software. Examples of studies using cross-sectional design from international peer-reviewed literature are also presented. This article provides general introduction to cross-sectional studies and does not substitute specialized literature in clinical epidemiology.
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2015 year | Issue: 2 | Pages: 5-18
MANAGEMENT MODEL BY MEDICAL PERSONNEL’S MOTIVATION ON THE EXAMPLE OF THE REGIONAL ONCOLOGY CENTER OF SEMEY
The paper presents a model of motivational management by medical staff of Regional oncology center of Semey city, on the basis of which is situated the chair of oncology and radiology named after D.R. Mussinov, MD, professor. At the chair are trained on the residency program, magistracy, Ph doctoral program. Staff motivation is set out in the form of implementation of the Program development of oncological cancer care in 2012-2015 years, including the development of nuclear medicine. Creation of highly efficient and motivated teams, including in health care institutions, will increase labor pr...
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2015 year | Issue: 1 | Pages: 70-76
НEALTH STATUS OF THE MODERN PUPILS
This article contains an analysis of the role of the negative tendencies in the dynamics of the pupils’ health status and the school education system in creating and maintaining the health of the younger generation.
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2015 year | Issue: 1 | Pages: 55-59
ORGANIZATION OF PREVENTIVE WORK IN PRIMARY HEALTH CARE IN HEALTH CARE REFORM AND WAYS TO IMPROVE
The paper provided an overview of the literary features and improving the organization of preventive work with the 20 years of the last century in the health sector.
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2015 year | Issue: 1 | Pages: 43-54