COGNITIVE IMPAIRMENT IN PATIENTS WITH CHRONIC VIRAL HEPATITIS IN THE TURKESTAN REGION
Introduction. Cognitive disorders in patients with chronic viral hepatitis can develop at different times after infection, due to their direct and indirect neurotoxic effects on the brain. In 50% of those infected with chronic viral hepatitis C, both clinical and subclinical manifestations of cognitive dysfunction can be detected. Timely diagnosis of cognitive disorders in patients with chronic viral hepatitis can serve as an indication for timely therapeutic measures aimed at improving the quality of life in this category of patients. This article discusses cognitive disorders in patients with chronic viral hepatitis in the Turkestan region.
Purpose: to study the qualitative and quantitative characteristics of cognitive functions in chronic viral hepatitis, with an assessment of the relationship between the severity of cognitive disorders between the stages of liver fibrosis and the duration of the disease, which are registered in the Regional Hepatological Center of Shymkent.
Material and methods. Prospective cohort study. 149 patients with chronic viral hepatitis registered at the Regional Hepatological Center in Shymkent were examined. The analysis of cognitive status was carried out using the Montreal Scale of Cognitive Functions of the MoCa. We used descriptive statistics, the Shapiro-Wilk statistical test, and correlation analysis using the nonparametric Spearman test for two linear variables.
Results and discussions. The results of the correlation analysis showed a weak negative relationship (r=-0.43, p < 0.04) between the MoСa parameters and the stage of liver fibrosis, which indicates moderate cognitive impairment in chronic viral hepatitis.
Conclusions. In patients with chronic viral hepatitis at various stages of fibrosis, in most cases, visual-constructive and executive skills, attention, short-term memory, and abstract thinking were impaired. The establishment of cognitive dysfunction of various degrees of severity, in particular at an early stage in patients with chronic viral hepatitis, contributes to the timely implementation of therapeutic measures aimed at improving the quality of life.
Tatyana V. Polukchi1-2, https://orcid.org/0000-0002-6134-884X,
Yelena A. Slavko1, https://orcid.org/0000-0001-6335-6125,
Gulzhan N. Abuova2, https://orcid.org/0000-0002-1210-2018,
Tatyana. V. Kasymova3, https://orcid.org/0000-0002-5695-5290
1 Asfendiyarov Kazakh National Medical University, Almaty, Republic of Kazakhstan;
2 South Kazakhstan Medical Academy, Shymkent, Republic of Kazakhstan;
3 Hepatological Center of the Regional Clinical Hospital, Shymkent, Republic of Kazakhstan.
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Polukchi T.V., Slavko Ye.A., Abuova G.N., Kasymova T.V. Cognitive impairment in patients with chronic viral hepatitis in the Turkestan region // Nauka i Zdravookhranenie [Science & Healthcare]. 2022, (Vol.24) 2, pp. 71-77. doi 10.34689/SH.2022.24.2.009Related publications:
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