CARDIOVASCULAR DISORDERS IN VARIOUS TYPES OF MODERN CHEMICAL DEPENDENCIES: COMPARATIVE ANALYSIS OF ROUTINE LABORATORY AND INSTRUMENTAL INDICATORS.
Introduction. Currently, there is a high prevalence of the use of psychoactive substances (surfactants) all over the world. Among the patients of the narcological service, people with both opioid monodependence and non-opioid poly-dependence (new psychoactive substances (NPSs), tropicamide (mydriacil), cannabis and others) are embedded. The question of the effect of these substances on the cardiovascular system remains poorly understood.
The aim of our study was to carry out a comparative characterization of routine clinical, laboratory and electrocardiographic parameters at patients with monodependence on opioids and poly dependence on cannabinoids, NPSs and tropicamide (mydriacil).
Materials and methods. An observational, cross-sectional study (with a retrospective set of cases) was conducted with the copying of anamnestic, laboratory, instrumental data from medical histories from 2015 to 2020. Statistical analysis was carried out in the IBM SPSS Statistics 20 program. The division into groups was carried out according to the following principle: opioid mono-dependence versus dependence on NPSs, cannabis, tropicamide. Descriptive statistical methods were used, comparative analysis of quantitative variables was carried out using the Student's t criterion, qualitative – Pearson's X2, for binary variables, the prevailing odds ratio and their 95% confidence intervals were additionally calculated.
Results. The research involved 375 people with opioid mono–dependence (69% of men, 31% of women), 191 - poly-dependence on NPSs, cannabis, tropicamide (88% of men, 12% of women). The average age of patients was 32±7.3. In patients with non-piodic poly-dependence, compared with opioid mono-dependence, hemoglobin and hematocrit indicators did not exceed the limits of reference values, but were statistically significantly higher. Elevated rates of hepatic transaminases were significantly higher among patients with monoadependency on opioids. A greater number of pathological shifts were found in ECG characteristics with poly–dependence on cannabinoids, NSAIDs and tropicamide: the chance of violations of repolarization processes with poly-dependence was 2.17 times higher (1.35; 3.47), and left ventricular hypertrophy was 2.08 times higher (1.29; 3.33).
Conclusions. These findings in routine examinations indicate increased risks of cardiovascular disorders in modern types of addictions (poly-dependence on cannabinoids, NPSs, tropicamide) and require further in-depth study of pathogenetic mechanisms, including using echocardiographic method and evaluation of an expanded range of laboratory parameters of blood clotting, unavailable in routine use in practical narcology.
Ainur М. Shukimbayeva1,2, https://orcid.org/0000-0002-4240-3663
Maria V. Prilutskaya1,2, https://orcid.org/0000-0002-9099-316X
Jamila A. Mansurova3, https://orcid.org/0000-0003-2439-2056
Ernar K. Kairkhanov1, https://orcid.org/0000-0001-7289-3272
Bakhytzhan E. Kenenbayeva1
1 Pavlodar branch of NJSC «Semey Medical University», Pavlodar c., Republic of Kazakhstan;
2 Branch of the RSE on REM «Republican Scientific and Practical Center for Mental Health» of the Ministry of Health of the Republic of Kazakhstan, Pavlodar c., Republic of Kazakhstan;
3 NJSC «Semey Medical University», Semey c., Republic of Kazakhstan.
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Shukimbayeva A.М., Prilutskaya M.V., Mansurova J.A., Kairkhanov E.K., Kenenbayeva B.E. Cardiovascular disorders in various types of modern chemical dependencies: comparative analysis of routine laboratory and instrumental indicators // Nauka i Zdravookhranenie [Science & Healthcare]. 2022, (Vol.24) 4, pp. 108-114. doi 10.34689/SH.2022.24.4.014Related publications:
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