Introduction: Kazakhstan belongs to the countries with a high incidence and mortality from corpus uteri cancer (CUC). According to the level of morbidity, standardized by age, it is among the 10 most common types of malignant neoplasms. And in the structure of morbidity among women, CUC occupies the 5th place (6.3%). Aim: To study the epidemiological features of the incidence of uterine body cancer and its spatial and temporal assessment in Kazakhstan. Materials and methods. A retrospective study was conducted for the period 2009-2018. Descriptive and analytical methods of epidemiology were used. Crude, age-standardized, equalized incidence rates and approximations were calculated. The cartogram compilation method based on the determination of the standard deviation (σ) from the mean value (x) was applied. Results. During the study period, 10,522 new cases of CUC were registered. The average annual age-standardized incidence rate was 11.1±0.2 cases per 100,000 female population (T=+0.6%; R2=0.083). When compiling cartograms, incidence rates were determined on the basis of standardized indicators: low – up to 8.9, average – from 8.9 to 12.6, high – above 12.6 per 100,000 female population. The results of the spatial analysis showed regions with a higher incidence of CUC per 100,000 female population: Pavlodar, Kostanay, Karaganda, Almaty, Northern Kazakhstan and Astana. Conclusions. In recent years, the incidence of CUC in Kazakhstan has been growing. High incidence rates were found in the northern regions of the country, and the trend of increasing incidence was more pronounced in the western and eastern regions.
Zhansaya B. Telmanova1-3, Aida Zh. Baybusunova1-3, Gulnur S. Igissinova4,1, Zarina A. Bilyalova1, Zhanar Zh. Kozhakhmetova1,2, Zhanerke R. Azhetova1,2, Serikbay T. Orozbaev2, Kuanish T. Kulayev5, Yerlan K. Kuandykov5, Nurbek S. Igissin1-3, 1 Central Asian Institute for Medical Research, Astana, the Republic of Kazakhstan; 2 Astana Medical University, Astana, the Republic of Kazakhstan; 3 Eurasian Institute for Cancer Research, Bishkek, the Kyrgyz Republic; 4 Asfendiyarov Kazakh National Medical University, Almaty, the Republic of Kazakhstan; 5 Khoja Akhmet Yassawi International Kazakh-Turkish University, Shymkent, the Republic of Kazakhstan.
1. Бокаева М.И., Жабагин К.Т., Семенова Ю.М., Даулетьярова М.А. и др. Заболеваемость и смертность от рака эндометрия в Республике Казахстан за 5-летний период (с 2012 по 2016 гг) // Наука и Здравоохранение. 2018. 20(2). С. 67-77. 2. Бюро национальной статистики Агентства стратегического планирования и реформ Республики Казахстан. (Дата обращения 23.06.2022). 3. Гланц С. Медико-биологическая статистика. Москва: Практика, 1999, 460 с. 4. Закон Республики Казахстан от 19 марта 2010 года № 257-IV “О государственной статистике”. (Дата обращения 22.06.2022). 5. Игисинов Н.С., Балтакаева А.М. Пространственная оценка заболеваемости ожирением в Казахстане // Молодой ученый. 2011. 2(25), С. 153-156. 6. Игисинов С.И. Способ составления и применения картограмм в онкологической практике // Здрав. Казахстана. 1974. 2, С. 69-71. 7. Козгамбаева Л.Т., Тулеуов А.Е., Оразбеков Б.С. Эпидемиология рака тела матки в г. Астана // Сибирский онкологический журнал. 2007. 2, С 57. 8. Мерков А.М., Поляков Л.Е. Санитарная статистика. Ленинград: Медицина, 1974 г, 384 с. 9. Онлайн-Статистический калькулятор. (Дата обращения 21.05.2022). 10. Шакирова А.Ф. Динамика заболеваемости раком тела матки в Карагандинской области и их возрастные особенности // Тюменский медицинский журнал. 2014. 1(4), С. 7-9 11. Ahmad O.E., Boschi-Pinto C., Lopez A.D., et al. Age standardization of rates: a new who standard. GPE Discussion Paper Series: No.31 EIP/GPE/EBD World Health Organization. 2001. 12. Amant F., Mirza M.R., Koskas M., Creutzberg C.L. Cancer of the corpus uteri // Int J Gynaecol Obstet. 2018. 143(2), P. 37-50. 13. Arnold M., Pandeya N., Byrnes G., Renehan A.G. et al. Global burden of cancer attributable to high body-mass index in 2012: a population-based study // Lancet Oncol. 2015. 16, P 36-46. 14. Banas T., Juszczyk G., Pitynski K. et al. Incidence and mortality rates in breast, corpus uteri, and ovarian cancers in Poland (1980-2013): an analysis of population-based data in relation to socioeconomic changes // Onco Targets Ther. 2016. 9, P. 5521-5530. 15. Bray F., Loos A.H., Oostindier M., Weiderpass E. Geographic and temporal variations in cancer of the corpus uteri: incidence and mortality in pre- and postmenopausal women in Europe // Int J Cancer. 2005. 117(1), P. 123-131. 16. Cust A.E. Physical activity and gynecologic cancer prevention // Recent Results Cancer Res. 2011. 186, P. 159‐185. 17. dos Santos I.S. Cancer epidemiology: principles and methods. Lyon, France, IARC, 1999, 442 p. 18. Felix A.S., Brinton L.A. Cancer Progress and Priorities: Uterine Cancer // Cancer Epidemiol Biomarkers Prev. 2018. 27(9,) P. 985-994. 19. Ferlay J., Ervik M., Lam F. et al. Global Cancer Observatory: Cancer Today. Lyon, France: International Agency for Research on Cancer. 2020. Available from: (accessed 30.07.2022). 20. Khazaei Z., Goodarzi E., Sohrabivafa M., Naemi H., Mansori K. Association between the incidence and mortality rates for corpus uteri cancer and human development index (HDI): a global ecological study // Obstet Gynecol Sci. 2020. 63(2), P. 141-149. 21. Lai J.C., Weng C.S., Huang S.M. et al. Incidence and lifetime risk of uterine corpus cancer in Taiwanese women from 1991 to 2010 // Taiwan J Obstet Gynecol. 2017. 56(1), P. 68-72. 22. Lortet-Tieulent J., Ferlay J., Bray F. et al. International patterns and trends in endometrial cancer incidence, 1978-2013 // J Natl Cancer Inst. 2018. 110, P. 354–361. 23. Lu K.H., Broaddus R.R. Endometrial Cancer // N Engl J Med. 2020. 383(21), P. 2053-2064. 24. Ma J.Y., Zhou Y., Lin Y.T. et al. Incidence and mortality of corpus uteri cancer in China, 2015 // Zhonghua Zhong Liu Za Zhi [Chinese journal of oncology]. 2021. 43(1), P. 108-112. 25. Renehan A.G., Tyson M., Egger M., Heller R.F., Zwahlen M. Body‐mass index and incidence of cancer: a systematic review and meta‐analysis of prospective observational studies // Lancet. 2008. 371, P. 569‐578. 26. Sidorenko A., Eshmanova A., Abikulova A. Aging of the Population in Kazakhstan. 1. Problems and Opportunities // Advances in Gerontology. 2018. 8(1), P. 12–21. 27. Sighoko D. Ethnic and geographic variations in corpus uteri cancer burden: evidence based on data from 29 states and the District of Columbia. CI5 IX, X and SEER data (1998-2010) // Cancer Causes Control. 2014. 25(9), P. 1197-1209. 28. Smith R.A., Manassaram-Baptiste D., Brooks D. et al. Cancer screening in the United States, 2014: a review of current American Cancer Society guidelines and current issues in cancer screening // CA Cancer J Clin. 2014. 64, P. 30–51. 29. Telmanova Z., Igissinova G., Igissinov N. Corpus uteri cancer in Kazakhstan: component analysis of incidence dynamics // Medicina (Kaunas). 2021. 57(1), P 119. 30. Wartko P., Sherman M.E. et al. Recent changes in endometrial cancer trends among menopausal-age U.S. women // Cancer Epidemiol. 2013. 37(4), P. 374-377. 31. WMA Declaration of Helsinki – Ethical Principles for Medical Research Involving Human Subjects. 2013. Available from: (Accessed 24.06.2022). References:[1-10] 1. Bokayeva M., Zhabagin K., Semenova Y., et al. Zabolevaemost' i smertnost' ot raka endometriya v Respublike Kazahstan za 5 letnij period (s 2012 po 2016 gg) [Mortality and morbidity from endometric cancer in the Republic of Kazakhstan from 2012 to 2016]. Nauka i Zdravookhranenie [Science & Healthcare]. 2018. 20(2), pp. 67-77. [in Russian] 2. Byuro nacional'noj statistiki Agentstva po strategicheskomu planirovaniyu i reformam Respubliki Kazahstan [The Bureau of National Statistics of the Agency for Strategic Planning and Reforms of the Republic of Kazakhstan]. Available from: (Accessed 23.06.2022). 3. Glanc S. Mediko-biologicheskaya statistika [Biomedical statistics]. Moscow, Praktika [Practice], 1999, 460 p. [in Russian] 4. Zakon Respubliki Kazahstan ot 19 marta 2010 goda № 257-IV “O gosudarstvennoj statistike” [The Law of the Republic of Kazakhstan No. 257-IV of March 19, 2010 “About State statistics”]. Available from: (accessed 22.06.2022). [in Russian] 5. Igissinov N., Baltakaeva A. Prostranstvennaya otsenka zabolevaemosti ozhireniem v Kazakhstane [Spatial assessment of the incidence of obesity in Kazakhstan]. Molodoi uchenyi [Young scientist]. 2011). 2(25), P 153-156. [in Russian] 6. Igissinov S.I. Sposob sostavleniya i primeneniya kartogramm v onkologicheskoi praktike [Preparation and application method of cartograms in oncology]. Zdravookhranenie Kazakhstana [Healthcare of Kazakhstan]. 1974. 2, P 69-71. [in Russian] 7. Kozgambayeva L.T., Tuleuov A.E., Orazbekov B.S. Epidemiologiya raka tela matki v g. Astana [Epidemiology of uterine body cancer in Astana]. Sibirskii onkologicheskii zhurnal [Siberian oncological journal]. 2007. 2, P 57. [in Russian] 8. Merkov A.M., Polyakov L.E. Sanitarnaya statistika [Sanitary statistics]. Leningrad, Meditsina [Medicine], 1974, 384 p. [in Russian] 9. Online Statistical Calculator. Available from: (accessed 21.05.2022). 10. Shakirova A.F. Dinamika zabolevaemosti rakom tela matki v Karagandinskoi oblasti i ih vozrastnie osobennosti [Dynamics of the incidence of uterine body cancer in the Karaganda region and their age characteristics]. Tyumenskii meditsinskii zhurnal [Tyumen Medical Journal]. 2014. 1(4), P. 7-9. [in Russian]
Number of Views: 42

Key words:

Bibliography link

Telmanova Zh.B., Baybusunova A.Zh., Igissinova G.S., Bilyalova Z.A., Kozhakhmetova Zh.Zh., Azhetova Zh.R., Orozbaev S.T., Kulayev K.T., Kuandykov Y.K., Igissin N.S. Geographical variability of corpus uteri cancer incidence in Kazakhstan // Nauka i Zdravookhranenie [Science & Healthcare]. 2023, (Vol.25) 1, pp. 115-122. doi 10.34689/SH.2023.25.1.015

Авторизируйтесь для отправки комментариев