HERPESVIRUS INFECTION IN CHILDREN IN THE ETIOLOGY OF HEMORRHAGIC VASCULITIS
Relevance. There is no predominant agent in the etiological structure of hemorrhagic vasculitis; instead, several factors play a role, including the activation of herpesvirus infections in the disease development. The objective of the study is determined by contradictory data and a lack of coordinated agreement regarding the etiology of hemorrhagic vasculitis.
Objective: To identify the role of herpesvirus infection in the etiology of hemorrhagic vasculitis in children.
Materials and methods. A cross-sectional study was conducted for 25 children aged from 2 months to 18 years with hemorrhagic vasculitis, who were on inpatient treatment at Medical Center "Children's Hospital" in Aktobe. All children underwent an enzyme-linked immunosorbent assay (ELISA) for herpesviruses: herpes simplex virus types I, II, (HSV-I, II), Epstein - Barr virus (EBV), cytomegalovirus (CMV), human herpesvirus type 6 (HHV – 6). The received data is processed by descriptive statistics, STATISTICS 10.0.
Results The herpesvirus infection was confirmed in 100% of the examined children, with herpes simplex virus I and II types being discovered in 25.9% of cases, Epstein-Barr virus in 28.46% of cases, cytomegalovirus (CMV) in 29.6% of cases, and human herpesvirus 6 (HHV-6) in 16% of cases. Moreover, they did not occur as mono-infections but rather in conjunction with the cytomegalovirus: CMV+ HSV-I, II (16 %); CMV+ EBV (8%); CMV+ HHV-6 (4%); CMV+ EBV+ HHV-6 (32%); CMV+ HSV-I, II + EBV+ HHV-6 (40%). A low concentration of herpesvirus antibodies in the blood of patients with hemorrhagic vasculitis was detected by ELISA anti-CMV IgG (11.62 U / ml), anti-HHV-6 IgG (6.82 U/ml), which indicates unstable immunity, the risk of activation of viral infection and recurrent hemorrhagic vasculitis.
Conclusion. According to the study, herpesvirus infections can lead to hemorrhagic vasculitis in children. If vasculitis recurs, it is advised to check for the presence of antibodies to herpesvirus antigens; if so, an infectious neurologist's consultation and etiotropic antiviral therapy are advised.
Zhamilya Issanguzhina1, https://orcid.org/0000-0002-7557-8486
Marziya Mamyrbayeva1, https://orcid.org/0000-0003-3138-4628
Svetlana Kim1, https://orcid.org/0000-0002-0145-9150
Galina Zhumagaliyeva1, https://orcid.org/0000-0002-5448-072Х
Akmanat Shilmanova1, https://orcid.org/0000-0002-3139-1193
Gulmira Ismambetova1, https://orcid.org/0000-0001-9451-3621
Natalya Pukhovikova1, https://orcid.org/0000-0003-3830-749X
Gulmira Kuldeyeva1, https://orcid.org/0000-0003-0081-0700
Zhadyra Zhalgasbayeva1, https://orcid.org/0000-0003-2579-2633
1 West Kazakhstan Marat Ospanov Medical University, Aktobe, Republic of Kazakhstan.
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Issanguzhina Zh., Mamyrbayeva M., Kim S., Zhumagaliyeva G., Shilmanova A., Ismambetova G., Pukhovikova N., Kuldeyeva G., Zhalgasbayeva Zh. Herpes viral infection in children in the etiology of hemorrhagic vasculitis // Nauka i Zdravookhranenie [Science & Healthcare]. 2023, (Vol.25) 2, pp. 160-165. doi 10.34689/SH.2023.25.2.022Related publications:
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