METABOLIC DISORDERS AND ENDOCRINE PATHOLOGY IN PREGNANCY
Background. The endocrine system provides close bilateral hormonal connections in pregnancy. This is responsible for the physiological course of gestation and successful delivery. Endocrine disorders can cause complications that can be often fatal. In such way we can have a talk about dysfunctions of the thyroid gland (TG) that have a significant impact on embryogenesis.
Aim was the study the endocrine pathology in pregnant women at the example of the Aktobe Medical Center (Aktobe).
Materials and Methods. A retrospective uncontrolled study was conducted. The materials were the data of the primary medical records (198 medical records) of the maternity ward and obstetric department of the Aktobe Medical Center for 2018 and 2019. The average women's age was 29.03±6.1. We analyzed medical and obstetric history, clinical signs and obstetric characteristics of pregnancy, and the hematological study's results. Statistical analysis was carried out using the statistical package STATISTICS, version 10, taking into account the reliability coefficient (p≤0.05).
Results. Endocrine pathologies were revealed in 31,3% of pregnant according to the studied records. Among them, 87.1% were diagnosed with thyroid dysfunction, obesity – 12.9%, and diabetes mellitus in 1.6% (they require a detailed examination, control, and correction to minimize the effect on the body of both the mother and the child). Among the diagnosed pathologies of the thyroid gland (n=54), the predominant majority had hypothyroidism (n=47, 87%) and 7 patients (13%) had hyperthyroidism of the thyroid gland. According to laboratory studies (TSH 7.8 ± 0.7 mIU /L; T4f within the reference values), latent hypothyroidism was recorded in patients. This is fraught with the development of extragenital pathology and negative effects on fetal development.
Conclusions. Thyroid dysfunction is a severe threat in obstetric practice. A retrospective analysis allows us to assess the endemicity of the region and focus on the pre-symptomatic diagnosis of disorders in the concentration of thyroid-stimulating hormones. Our results confirm the need of diagnosing endocrine pathologies, and hypothyroidism as a part, at an early stage with subsequent correction.
Raisa Aringazina*1, https://orcid.org/0000-0003-1186-7796
Zhansulu Nurgaliyeva1, https://orcid.org/0000-0001-8732-5833
Nurgul Zholdassova1, https://orcid.org/0000-0002-4289-9195
Ainur Donayeva1, https://orcid.org/0000-0002-7363-0789
Indira Kaibagarova1, https://orcid.org/0000-0001-8732-5833
1 Non-Commercial Joint-Stock Society West Kazakhstan Marat Ospanov Medical University,
Aktobe, Republic of Kazakhstan.
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Aringazina R., Nurgaliyeva Zh., Zholdassova N., Donayeva A., Kaibagarova I. Metabolic disorders and endocrine pathology in pregnancy // Nauka i Zdravookhranenie [Science & Healthcare]. 2023, (Vol.25) 2, pp. 90-96. doi 10.34689/SH.2023.25.2.013Related publications:
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