CLINICAL AND PROGNOSTIC FEATURES OF THE RESPIRATORY STATUS OF CONGENITAL PNEUMONIA IN PREMATURE NEWBORNS WITH VITAMIN D DEFICIENCY
According to WHO, pneumonia kills more children than any other infectious disease, annually claiming the lives of more than 700,000 children under the age of five, or about 2,000 every day. This includes more than 200,000 newborns. Almost all of these deaths can be prevented [20]. Vitamin D, which is formed in tissues, is responsible for many immunomodulatory actions of vitamin D. The effects of vitamin D in the lungs include increased secretion of the antimicrobial peptide cathelicidin, decreased production of chemokines, inhibition of activation of dendritic cells and changes in T cells [5].
Objective: The study was aimed at determining the concentration of vitamin D in the blood serum of premature newborns with congenital pneumonia and assessing their respiratory status.
Materials and methods: case - control. The study was conducted on the basis of the Regional Perinatal Center of Semey, Republic of Kazakhstan. The study included premature newborns in the number of 228 children. Informational consents were received from mothers of newborns to participate in the study. The mothers were informed about the processing of the received data, with the subsequent publication of the research results, without specifying personal data. Inclusion criteria: premature newborns (gestation period from 22 weeks to 37 weeks). Exclusion criteria: children with malformations, genetic diseases, full-term newborns. The data analysis was carried out using the SPSS package version 20.0. To check the statistical significance of the differences between the group of "cases" and "controls", the Pearson criterion χ2 is used, and the odds ratio is calculated taking into account the 95% confidence interval. Continuous data is presented in the form of (M) and standard deviation (CO).
Results: We report on the seasonality of preterm labor, antenatal steroid prevention, vitamin D levels, the time of occurrence of congenital pneumonia, the duration of respiratory support: IVL, ventilator, nasal cannulas, the frequency of surfactant replacement therapy techniques, as well as the average stay of patients in the intensive care unit in groups with congenital pneumonia and without congenital pneumonia of premature newborns.
Conclusion: Thus, according to the results of our study, a low concentration of vitamin D in the blood serum may be largely associated with neonatal pneumonia.
Gulnarа B. Taiorazova1, https://orcid.org/0000-0002-8450-9204
Aliya R. Alimbaeva1, https://orcid.org/0000-0002-5082-4636
Sayat Z. Tanatarov1, https://orcid.org/0000-0001-8958-8768
Nazym М. Ailbayeva1, https://orcid.org/0000-0003-1700-9696
Danara М. Imanmadiyeva1, https://orcid.org/0000-0002-7772-9727
Dinara О. Ahmetzhanova1, https://orcid.org/0000-0003-0000-2535
Manshuk N. Nazarbekova1, https://orcid.org/0000-0003-1364-1512
Yernar Ye. Dairbekov1, https://orcid.org/0000-0002-5522-7312
Arailym A. Kapanova1, https://orcid.org/0000-0001-5660-1460
Duman Berikuly1, https://orcid.org/0000-0002-9738-7453
Dinara Zh. Sabitova1, https://orcid.org/0000-0001-7473-7126
Yuri F. Lobanov2, https://orcid.org/0000-0001-6284-1604
1 NJSC Semey Medical University, Semey, Republic of Kazakhstan;
2 Altai State Medical University, Barnaul, Russian Federation.
1. Aldana-Aguirre J.C., Pinto M., Featherstone R.M., Kumar M. Less invasive surfactant administration versus intubation for surfactant delivery in preterm infants with respiratory distress syndrome: a systematic review and meta-analysis // Arch Dis Child Fetal Neonatal. 2017; 102(1): 17-23.
2. Boskabadi H., Mamoori G., et al. Serum level of vitamin D in preterm infants and its association with premature-related respiratory complications: a case-control study // Electron Physician. 2018. 25. 10(1):6208-6214.
3. El-Kassas G.M., El-Wakeel M.A., Elabd M.A., Kamhawy A.H., Atti M.A., El-Gaffar S.A.A., Hanafy S.K., Awadallah E. Vitamin D Status in Neonatal Pulmonary Infections: Relationship to Inflammatory Indicators // Open Access Maced J Med Sci. 2019; 14;7(23):3970-3974.
4. Fettah N., Zenciroğlu A., Dilli D., Beken S., Okumuş N. Is Higher 25-Hydroxyvitamin D Level Preventive for Respiratory Distress Syndrome in Preterm Infants? // American Journal of Perinatology. 2014;32(3): 247–250.
5. Hansdottir S., Monick M.M. Vitamin D effects on lung immunity and respiratory diseases // Vitam Horm. 2011; 86:217-237.
6. Iqbal Q., Younus M.M., Ahmed A., Ahmad I., Iqbal J., Charoo B.A., Ali S.W. Neonatal mechanical ventilation: Indications and outcome // Indian J Crit Care Med. 2015; 19(9): 523-527.
7. Lezhenko G., Pashkova O., Kraynya H. The vitamin D deficiency as a marker of risk of pneumonia among children under 3 years // Biological Markers and Guided Therapy. 2016. 3(1): 99-106.
8. Mwansa-Kambafwile J., Cousens S., Hansen T., Lawn J.E. Antenatal steroids in preterm labour for the prevention of neonatal deaths due to complications of preterm birth // Int J Epidemiol. 2010; 39(1): 122-133.
9. Özkan B., Döneray H. Non-skeletal effects of vitamin D // Çocuk Sağılığı ve Hastalıkları Dergisı. 2011; 54: 99–119
10. Reuter S., Moser C., Baack M. Respiratory distress in the newborn // Pediatr Rev. 2014; 35(10):417-428;
11. Sanjay S. Overview of Pneumonia. University at Buffalo, Jacobs School of Medicine and Biomedical Sciences. 2022; https://www.msdmanuals.com/home/lung-and-airway-disorders/pneumonia/overview-of-pneumonia (Дата обращения: 17.08.2022г.)
12. Schmölzer G.M., Kumar M., Pichler G., Aziz K., O'Reilly M., Cheung P.Y. Non-invasive versus invasive respiratory support in preterm infants at birth: systematic review and meta-analysis // BMJ. 2013; 17: 347
13. Sharma A.A., Jen R., Butler A., Lavoie P.M. The developing human preterm neonatal immune system: a case for more research in this area // Clin Immunol. 2012; 145(1):61-68.
14. Stevens T.P., Harrington E.W., Blennow M., Soll R.F. Early surfactant administration with brief ventilation vs. selective surfactant and continued mechanical ventilation for preterm infants with or at risk for respiratory distress syndrome // Cochrane Database Syst Rev. 2007 Oct 17;2007(4):CD003063.
15. Sweet D.G., Carnielli V., Greisen G., Hallman M., Ozek E., Te Pas A., et al. European Consensus Guidelines on the Management of Respiratory Distress Syndrome // Update. Neonatology. 2019; 115(4):432-450.
16. Tesini B.L. Neonatal Pneumonia. University of Rochester School of Medicine and Dentistry. 2022; https://www.msdmanuals.com/professional/pediatrics/infections-in-neonates/neonatal-pneumonia) (Дата обращения: 3.01. 2022г.)
17. Thandrayen K., Pettifor J.M. Maternal vitamin D status: implications for the development of infantile nutritional rickets // Endocrinol Metab Clin North Am 2010; 39(2): 303–320
18. Weinberger S.E., Cockrill B.A., Mandel J. Pneumonia // Principles of Pulmonary Medicine. 2019; 297–313.
19. Zaidi A.K.M., Ganatra H.A., Syed S. Effect of case management on neonatal mortality due to sepsis and pneumonia // BMC Public Health 2011; 11 (3): 13.
20. UNICEF: Monitoring the situation of children and women. Pneumonia. December 2022. https://data.unicef.org/topic/child-health/pneumonia). (Дата обращения: 03.01 2022г.)
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Taiorazova G.B., Alimbaeva A.R., Tanatarov S.Z., Ailbayeva N.М., Imanmadiyeva D.М., Ahmetzhanova D.О., Nazarbekova M.N., Dairbekov Ye.Ye., Kapanova A.A., Berikuly D., Sabitova D.Zh., Lobanov Yu.F. Clinical and prognostic features of the respiratory status of congenital pneumonia in premature newborns with vitamin D deficiency // Nauka i Zdravookhranenie [Science & Healthcare]. 2023, (Vol.25) 3, pp. 144-151. doi 10.34689/SH.2023.25.3.019Related publications:
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