A PROSPECTIVE STUDY ON THE ROLE OF VITAMIN D DEFICIENCY IN CHILDREN BORN WITH MACROSOMIA
Relevance: Macrosomia is defined as a birth weight of more than 4000 g regardless of gestational age and occurs in 3-15% of all pregnancies worldwide [2,8,25]. Vitamin D deficiency during pregnancy is associated with an increased risk of gestational diabetes and preeclampsia, which may indirectly affect the health of offspring [3,4,18].
Objective: To assess the role of vitamin D, the health status of children born with macrosomia in the first year of life.
Materials and methods of research: a prospective study. The study was conducted in the period from January 2021 to April 2021 at the clinical base "Semey Perinatal Center". The study included full-term newborns in the number of 258 children. Informational consents were received from mothers of newborns to participate in the study. The mothers were informed about the processing of the received data, with the subsequent publication of the research results, without specifying personal data. Inclusion criteria: full-term children with macrosomia. Exclusion criteria: children with defects, genetic diseases, premature newborns.
The data analysis was carried out using the SPSS package version 20.0. To check the statistical significance of the differences between the group of "cases" and "controls", the Pearson and Fisher criterion χ2 was used, and the odds ratio is calculated taking into account the 95% confidence interval. Continuous data is presented in the form of (Me) and standard deviation (CD).
Results: Based on the analysis of the features of early adaptation of newborns with vitamin D deficiency and their health status in the first year of life. The study showed that the pronounced vitamin D deficiency in serum was significantly lower in patients with macrosomia compared to normal-weight children.
Conclusion: Thus, according to the results of our study, the early adaptation of newborn children with macrosomia was manifested with significant differences from children with normal weight. In a prospective follow-up of children with macrosomia, paratrophy was also noted in the first year of life.
Nazym М. Ailbayeva1, https://orcid.org/0000-0003-1700-9696
Aliya R. Alimbaeva1, https://orcid.org/0000-0002-5082-4636
Sayat Z. Tanatarov1, https://orcid.org/0000-0001-8958-8768
Gulnarа B. Taiorazova1, https://orcid.org/0000-0002-8450-9204
Danara М. Imanmadiyeva1, https://orcid.org/0000-0002-7772-9727
Dinara О. Ahmetzhanova1, https://orcid.org/0000-0003-0000-2535
Manshuk N. Nazarbekova1, https://orcid.org/0000-0003-1364-1512
Yernar Ye. Dairbekov1, https://orcid.org/0000-0002-5522-7312
Arailym A. Kapanova1, https://orcid.org/0000-0001-5660-1460
Duman Berikuly1, https://orcid.org/0000-0002-9738-7453
Oxana A. Yurkovskaya1, https://orcid.org/0000-0002-6251-5574
Yuri F. Lobanov2, https://orcid.org/0000-0001-6284-1604
1 NJSC «Semey Medical University», Semey, Republic of Kazakhstan;
2 Altai State Medical University, Barnaul, Russian Federation.
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Ailbayeva N.М., Alimbaeva A.R., Tanatarov S.Z., Taiorazova G.B., Imanmadiyeva D.М., Ahmetzhanova D.О., Nazarbekova M.N., Dairbekov Ye.Ye., Kapanova A.A., Berikuly D., Yurkovskaya O.A., Lobanov Yu.F. A prospective study on the role of vitamin D deficiency in children born with macrosomia // Nauka i Zdravookhranenie [Science & Healthcare]. 2023, (Vol.25) 3, pp. 152-158. doi 10.34689/SH.2023.25.3.020Related publications:
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