Introduction. Atopic dermatitis is a chronic relapsing inflammatory skin disease characterized by the appearance of eczematous and lichenoid rashes, as well as severe itching. This disease can cause psychological problems, both in the child himself and in his parents. Difficulties in caring for a child with atopic dermatitis can lead to emotional exhaustion in the mother, provoking symptoms of depression and anxiety. The purpose of our study was to investigate the relationship of anxiety and depression of mothers with clinical and anamnestic data of children with atopic dermatitis. Materials and methods. The cross-sectional study included 120 mothers of children with atopic dermatitis aged 2 months to 14 years inclusive. All children were assessed the severity of the course of the disease, the prevalence of the process, its form. To assess the psycho-emotional status of mothers, the GAD-7 questionnaires were used to determine the level of anxiety of a woman and PHQ-9 to determine the level of depression. Results. According to the results of our study, it was found that among children suffering from atopic dermatitis with higher prevalence in girls. Clinical manifestations of the disease, as a rule, begin at the age of two months to two years, and the predominant form is the erythematous-squamous form with limited localization of the disease and a mild course. Among the psycho-emotional disorders in mothers of children with atopic dermatitis, anxiety was most often observed. The presence of anxiety in the mother increases the likelihood of a moderate course of the disease in children by almost 1.5 times. At the same time, depression in the mother was not associated with any clinical and anamnestic factor of the disease. Conclusions. Timely diagnosis of anxiety and the implementation of measures aimed at reducing it in mothers of children suffering from atopic dermatitis can help reduce the likelihood of disease progression.
Assiya A. Kussainova1, Yerbol M. Nurkatov2*, Laura T. Kassym3, Almas A. Kussainov3, Ak-Uke S. Rakisheva3, Natalya A. Mukisheva4, Almira K. Akhmetova1, Zhanar A. Sakenova1 1 NJSC "Semey Medical University", Semey, Republic of Kazakhstan; 2 School of Medicine, Nazarbayev University, Astana, Republic of Kazakhstan; 3 NJSC "Astana Medical University", Astana, Republic of Kazakhstan; 4 SCE on the REM "Ekibastuz city hospital", Ekibastuz, Republic of Kazakhstan.
1. Богуславская Ю.А., Кудрявцева А.В., Свитич О.А., Макарова И.В. Особенности ведения детей с атопическим дерматитом в разных странах // Аллергология и иммунология в педиатрии // 2018. 4 (55), С. 30-37. 2. Кузиева Г.Д. Оптимизация ведения детей и подростков, больных атопическим дерматитом в городе Алматы // Вестник Казахского Национального медицинского университета. 2014. №. 2-4. С. 64-66. 3. Намазова-Баранова Л.С. и др. Атопический дерматит у детей: современные клинические рекомендации по диагностике и терапии // Вопросы современной педиатрии. 2016. Т. 15. №. 3. С. 279-294. 4. Шопабаева А.Р., Остемиркызы Д., Кубджанова А.Ж. Эпидемиологический и фармакоэкономический анализ лекарственных препаратов, применяемых при атопическом дерматите в республике Казахстан // Фармация Казахстана. 2021. №.4. С. 64-71. 5. Braig S., Weiss J.M., Stalder T., Kirschbaum C., Rothenbacher D., Genuneit J. Maternal prenatal stress and child atopic dermatitis up to age 2 years: The Ulm SPATZ health study // Pediatric Allergy and Immunology. 2017. 28(2), 144-151. 6. Chang H. Y., Suh D. I., Yang S. I., Kang M. J., Lee S. Y., Lee E., Hong S. J. Prenatal maternal distress affects atopic dermatitis in offspring mediated by oxidative stress // Journal of Allergy and Clinical Immunology. 2016. 138(2), 468-475. 7. Charfi F. et al. Аtopic dermatitis and mother-child interaction: a comparative study of 48 dyads Dermatite atopique et interaction mère-enfant: étude comparative de 48 dyades // La Tunisie medicale. 2018. Т. 96. №. 07. 8. Giesbrecht G.F., Campbell T., Letourneau N., Kooistra L., Kaplan B. APrON Study Team. Psychological distress and salivary cortisol covary within persons during pregnancy // Psychoneuroendocrinology. 2012. 37(2), 270-279. 9. Im Y.J., Park E.S., Oh W.O., Suk M.H. Parenting and relationship characteristics in mothers with their children having atopic disease // Journal of Child Health Care. 2014. 18(3), 215-229. 10. Kawaguchi C., Murakami K., Ishikuro M., Ueno F., Noda A., Onuma T., Obara T. Cumulative exposure to maternal psychological distress in the prenatal and postnatal periods and atopic dermatitis in children: findings from the TMM BirThree Cohort Study // BMC Pregnancy and Childbirth. 2022. 22(1), 242. 11. Letourneau N.L., Kozyrskyj A.L., Cosic N., et al. Maternal sensitivity and social support protect against childhood atopic dermatitis // Allergy, Asthma Clinical Immunology. 2017.13:26 12. Lin T.L., Fan Y.H., Chang Y.L., Ho H.J., Wu C.Y., Chen Y.J. Early-life infections in association with the development of atopic dermatitis in infancy and early childhood: a nationwide nested case-control study. // Journal of the European Academy of Dermatology and Venereology 2022 Apr;36(4):615-622. 13. Macht V.A. Neuro-immune interactions across development: a look at glutamate in the prefrontal cortex // Neuroscience & Biobehavioral Reviews. 2016. Т. 71. С. 267-280. 14. Manzoni A.P. et al. Assessing depression and anxiety in the caregivers of pediatric patients with chronic skin disorders // Anais Brasileiros de Dermatologia. 2013. Т. 88. С. 894-899. 15. Marin T.J., Chen E., Munch J.A., Miller G.E. Double-exposure to acute stress and chronic family stress is associated with immune changes in children with asthma // Psychosomatic medicine. 2009. 71(4), 378. 16. Pauli-Pott U., Darui A., Beckmann D. Infants with atopic dermatitis: maternal hopelessness, child-rearing attitudes and perceived infant temperament // Psychotherapy and psychosomatics. 1999. Т. 68. №. 1. С. 39-45. 17. Ricci G., Bendandi B., Aiazzi R., Patrizi A., Masi M. Three years of Italian experience of an educational program for parents of young children affected by atopic dermatitis: improving knowledge produces lower anxiety levels in parents of children with atopic dermatitis // Pediatric dermatology. 2009. 26(1), 1-5. 18. Ring J., Palos E., Zimmermann F. Psychosomatische Aspekte der Eltern Kind - Beziehung bei atopischem Ekzem im Kindesalter // Hautarzt. 1986.37:560-7 19. Seckl J.R., Holmes M.C. Mechanisms of disease: glucocorticoids, their placental metabolism and fetal'programming'of adult pathophysiology // Nature clinical practice Endocrinology & metabolism. 2007. Т.3. №.6. С. 479-488. 20. Thomas J.C., Letourneau N., Campbell T.S., Tomfohr-Madsen L., Giesbrecht G.F. Developmental origins of infant emotion regulation: Mediation by temperamental negativity and moderation by maternal sensitivity // Developmental psychology. 2017. 53(4), 611. 21. Ulmer‐Yaniv A., Djalovski A., Priel A., Zagoory‐Sharon O., Feldman R. Maternal depression alters stress and immune biomarkers in mother and child // Depression and anxiety. 2018. 35(12), 1145-1157. 22. Von Hertzen L.C. Maternal stress and T-cell differentiation of the developing immune system: possible implications for the development of asthma and atopy // Journal of Allergy and Clinical Immunology. 2002. Т.109. №.6. С. 923-928. 23. Wan M.W., Janta-Lipinski M., Osam C.S. Childhood allergies: The role of maternal depression and anxiety, and family strain // Children. 2021. Т.8. №.3. С.185. 24. Wang I.J., Wen H.J., Chiang T.L., Lin S.J., Guo Y.L. Maternal psychologic problems increased the risk of childhood atopic dermatitis // Pediatric Allergy and Immunology. 2016. 27(2), 169-176. 25. Weinberg M.K., Beeghly M., Olson K.L., Tronick E. Effects of maternal depression and panic disorder on mother–infant interactive behavior in the Face‐to‐Face Still‐Face paradigm // Infant Mental Health Journal: Official Publication of The World Association for Infant Mental Health. 2008. 29(5), 472-491. 26. Wen H.J., Wang Y.J., Lin Y.C., Chang C.C., Shieh C.C., Lung F.W., Guo Y.L. Prediction of atopic dermatitis in 2‐yr‐old children by cord blood IgE, genetic polymorphisms in cytokine genes, and maternal mentality during pregnancy // Pediatric Allergy and Immunology. 2011. 22(7), 695-703. 27. Wright R.J. Stress and atopic disorders // Journal of Allergy and Clinical Immunology. 2005. Т.116. №.6. С.1301-1306. 28. Wright R.J., Enlow M.B. Maternal stress and perinatal programming in the expression of atopy // Expert Review of Clinical Immunology. 2008. Т. 4. №. 5. С. 535-538. 29. Wright R.J., Finn P., Contreras J.P., Cohen S., Wright R.O., Staudenmayer J., Gold D.R. Chronic caregiver stress and IgE expression, allergen-induced proliferation, and cytokine profiles in a birth cohort predisposed to atopy // Journal of Allergy and Clinical Immunology. 2004. 113(6), 1051-1057. References: 1. Boguslavskaya Yu. A., Kudryavceva A. V., Svitich O. A., Makarova I. V. Osobennosti vedeniya detei s atopicheskim dermatitom v raznykh stranakh [Features of managing children with atopic dermatitis in different countries]. Allergologiya i immunologiya v pediatrii [Allergology and Immunology in Pediatrics]. 2018. 4 (55), pp. 30-37. [in Russian] 2. Kuzieva G. D. Optimizatsiya vedeniya detei i podrostkov, bol'nykh atopicheskim dermatitom v gorode Almaty [Optimization of the management of children and adolescents with atopic dermatitis in the Almaty city]. Vestnik Kazakhskogo Natsional'nogo meditsinskogo universiteta [Herald of the Kazakh National Medical University]. 2014. №2-4. pp. 64-66. [in Russian] 3. Namazova-Baranova L.S. i dr. Atopicheskii dermatit u detei: sovremennye klinicheskie rekomendatsii po diagnostike i terapii [Atopic dermatitis in children: current clinical guidelines for diagnosis and therapy]. Voprosy sovremennoi pediatrii [Questions of modern pediatrics]. 2016. T.15. №3. pp. 279-294. [in Russian] 4. Shopabaeva A. R., Ostemirkyzy D., Kubdzhanova A. Zh. Epidemiologicheskii i farmakoekonomicheskij analiz lekarstvennykh preparatov, primenyaemykh pri atopicheskom dermatite v respublike Kazakhstan [Epidemiological and pharmacoeconomic analysis of drugs used in atopic dermatitis in the Republic of Kazakhstan]. Farmatsiya Kazakhstana [Pharmacy of Kazakhstan]. 2021. №4. pp. 64-71. [in Russian]
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Kussainova A.A., Nurkatov Ye.M., Kassym L.T., Kussainov A.A., Rakisheva A.S., Mukisheva N.A., Akhmetova A.K., Sakenova Zh.A. Psycho-emotional stress in mother of children with atopic dermatitis // Nauka i Zdravookhranenie [Science & Healthcare]. 2023, 3 (Vol.25), pp. 159-166. doi 10.34689/SH.2023.25.3.021

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