EPIDEMIOLOGY OF MALIGNANT NEOPLASMS AMONG WOMEN LIVING IN THE ZONE OF INFLUENCE OF RADIOACTIVE WASTE STORAGE FACILITIES
Introduction. Kazakhstan holds 14% of the world's uranium reserves, accounting for almost 88% of world production in 2013. Previous studies indicate that indoor and outdoor gamma dose rates and radon concentrations in the area exceed acceptable limits. Current research is evaluating the impact of uranium radioactive waste storage facilities on cancer epidemiology in nearby areas.
Materials and methods. The study included critical and control zones. The critical zone included the cities of Aksu, Kvartsytka, Zavodskoy, Shantobe and Stepnogorsk, located less than 5 km south of the tailings of the Hydrometallurgical Plant, and in the control group - Akkolsky district, 90 km from the storage of radioactive waste. Data obtained from the Electronic Register of Cancer Patients of the Republic of Kazakhstan.
Results. A total of 2,271 cases of cancer were reported between 2001 and 2015. The prevalence of malignant neoplasms in the main group was 35.02 per 1000 population versus 26.4 per 1000 people in the control group (χ2 = 23.9, p = 0.00). The prevalence of oncological diseases among the female population living in the area of action of radioactive waste storage facilities was 17.55 per 1000 population and was also statistically significantly higher than this indicator in the control group - 12.88 (χ2 = 14.3, p = 0.00).
Conclusion. In general, the study indicates the negative impact of the tailings of the hydrometallurgical plant on the environment and the occurrence of cancer.
Kuralay B. Ilbekova1, https://orcid.org/0000-0001-9950-9808
Elena A. Saifulina1, https://orcid.org/0000-0002-1791-0137
Ainur O. Samigatova2, https://orcid.org/0000-0002-2919-8212
Danara S. Ibrayeva1, https://orcid.org/0000-0002-1640-1728
Moldir N. Aumalikova1, https://orcid.org/0000-0002-4242-9193
Polat K. Kazymbet1, https://orcid.org/0000-0003-3091-1721
Meirat M. Bakhtin1, https://orcid.org/0000-0001-6117-5101
Yerbol K. Dogalbaev2, https://orcid.org/0000-0001-8239-563X
1 Research Institute of Radiobiology and Radiation Protection NCJSC "Astana Medical University", Astana, Republic of Kazakhstan;
2 Multidisciplinary Medical Center of the Akimat of Astana, Astana, Republic of Kazakhstan;
3 “University Medical Center” Corporate Fund, Department of Interventional Radiology, Astana, Republic of Kazakhstan.
1. Дюсембеков Е.К. Заболеваемость населения злокачественными новообразованиями головного мозга в Казахстане // Центрально Азиатский научно-практический журнал по общественному здравоохранению, 2007. Т.6. № 2 – 3. С. 65–70.
2. Куценко И.Г., Карпов А.Б., Тахауов Р.М. и др. Долговременное профессиональное облучение здоровье женщин. Томск, 2014. С.6-7.
3. Казымбет К. Радиоэкологическое состояние территорий уранодобывающих районов Казахстана // Научные труды Института радиобиологии и радиационной защиты. 2014. 1,С 19-55.
4. Казымбет П., Бахтин М., Кашкинбаев Э., Джанабаев Д., Даутбаева З., Шарипов М. Радиационная обстановка на хвостохранилище Степногорского горно-химического комбината и прилегающих территориях. Сообщение I // Мед. Радиол. Радиа. Безопасность, 2001, Том. 63.1. С.40-47.
5. Михеева Г.Х., Гатауллин И.Г., Биктемирова Р.Г. Загрязнение окружающей среды фактор риска формирования заболеваемости онкологической патологией в ульяновской области // Тюменский медицинский журнал, 2012. № 4. С.20-22.
6. Петров Н.Н., Язиков В.Г., Аубакиров Х.Б. Урановые месторождения Казахстана (экзогенные) // Алматы: Гылым, 1995. С.264-530.
7. Смулевич В.Б., Ременник H. Демографические аспекты эпидемиологии злокачественных новообразований (науч.обзор) ВНИИМИ (обзор информация) // «Медицина и здравоохранение». - М., 1983., 92 с.
8. Aumalikova M. et al. Site‑specific concentration of uranium in urine of workersof the hydrometallurgical plant of Stepnogorsk mining and chemicalcombine// Radiation and Environmental Biophysics, 2020. vol.59. pp.703–710.
9. Doinikova O.A. Uranium deposits with a new phosphate type of blacks // Geology of Ore Deposits, 2007 vol. 49, no.1. рр. 80-86.
10. Karatayev M., Hall S., Kalyuzhnova Y., and Clarke M.L. Renewable energy technology uptake in Kazakhstan: Policy drivers and barriers in a transitional economy // Renewable and Sustainable Energy Reviews, 2016. vol. 66. pp. 120-136.
11. Kulhаnovа I., Znaor A., Shield K.D., Arnold M., Vignat J., Charafeddine M., Fadhil I., Fouad H., Al-Omari A., Saeed Al-Zahrani A., El-Basmy A., Shamseddine A., Bray F.I., Soerjomataram I. Proportion of cancers attributable to major lifestyle and environmental risk factors in the Eastern Mediterranean region // International Journal of Cancer, 2019. 18 March. DOI:10.1002/ijc.32284.
12. López-Abente G. et al. Residential radon and cancer mortality in Galicia, Spain // Science of the Total Environment, 2018. vol. 610. pp. 1125-1132.
13. Mederos N., Friedlaender A., Peters S., Addeo A. Gender-specific aspects of epidemiology, molecular genetics and outcome: lung cancer // ESMO open, 2020. vol. 5. Р.e000796.
14. Purdie D.M., Green A.C. Epidemiology of endometrial cancer // Best practice & research. Clinical obstetrics & gynecology, 2001.vol.15, no.3. pp. 341-354.
15. Robertson J.A., Laney R., Curnow A. The cellular and molecular carcinogenic effects of radon exposure: a review // International journal of molecular sciences, 2013, vol.14, no.7. pp. 14024-14063.
16. Turner M.C., Krewski D., Chen Y., Pope Iii C.A., Gapstur S.M., Thun M.J. Radon and nonrespiratory mortality in the American Cancer Society cohort // American Journal of Epidemiology, 2012 vol.176, no.9. pp.808-814.
17. World health statistics 2018: monitoring health for the SDGs, sustainable development goals. Geneva: World Health Organization; 2018. 96 p.
18. Wu Y., Sun W., Liu H., Zhang D. Age at menopause and risk of developing endometrial cancer: a meta-analysis // BioMed research international, vol. 2019. 13 p.
19. World Health Organization. Radon - fact sheets. 2023. URL: https://www.who.int/news-room/fact-sheets/detail/radon-and-health (25 January 2023).
References: [1-7]
1. Dyusembekov E.K. Zabolevaemost' naseleniya zlokachestvennymi novoobrazovaniyami golovnogo mozga v Kazakhstane [The incidence of malignant brain tumors in Kazakhstan.]. Tsentral'no - Aziatskii nauchno-prakticheskii zhurnal po obshchestvennomu zdravookhraneniyu [Central Asian Journal of Public Health], 2007. T.6. № 2–3. pp. 65–70. [in Russian]
2. Kutsenko I.G., Karpov A.B., Takhauov R.M. i dr. Dolgovremennoe professional'noe obluchenie zdorov'e zhenshchin [Long-term occupational radiation exposure and women's health].Tomsk, 2014. pp. 6-7. [in Russian]
3. Kazymbet K. Radioekologicheskoe sostoyanie territorii uranodobyvayushchikh raionov Kazakhstana [Radioecological status of territories in uranium mining regions of Kazakhstan]. Nauchnye trudy Instituta radiobiologii i radiatsionnoi zashchity [Scientific works of the Institute of Radiobiology and Radiation Protection]. 2014. 1, pp. 19-55. [in Russian]
4. Kazymbet P., Bakhtin M., Kashkinbaev E., Dzhanabaev D., Dautbaeva Z., Sharipov M. Radiatsionnaya obstanovka na khvostokhranilishche Stepnogorskogo gorno-khimicheskogo kombinata i prilegayushchikh territoriyakh. Soobshchenie I [Radiation situation at the tailings facility of the Stepnogorsk Mining and Chemical Combine and adjacent areas. Report I]. Med. Radiol. Radia. Bezopasnost' [Medical Radiology and Radiation Safety]. 2001, Tom. 63.1. pp. 40-47. [in Russian]
5. Mikheeva G.Kh., Gataullin I.G., Biktemirova R.G. Zagryaznenie okruzhayushchei sredy faktor riska formirovaniya zabolevaemosti onkologicheskoi patologiei v ul'yanovskoi oblasti [Environmental pollution as a risk factor for the development of oncological diseases in the Ulyanovsk region]. Tyumenskii meditsinskii zhurnal [Tyumen Medical Journal]. 2012. № 4. pp. 20-22. [in Russian]
6. Petrov N.N., Yazikov V.G., Aubakirov Kh.B. Uranovye mestorozhdeniya Kazakhstana (ekzogennye) [Uranium Deposits in Kazakhstan (Exogenous)]. Almaty: Gylym. [Almaty: Sciencе]., 1995. pp. 264-530.
7. Smulevich V.G., Remennik L.I. Demograficheskie aspekty epidemiologii zlokachestvennykh novoobrazovanii [Demographic Aspects of the Epidemiology of Malignant Neoplasms (Scientific Review) by VNIIMI (Information Review)]. Medicina i zdravoohranenie [Medicine and healthcare]., 2000. 92 p. [in Russian].
Number of Views: 122
Category of articles:
Original articles
Bibliography link
Ilbekova K.B., Saifulina E.A., Samigatova A.O., Ibrayeva D.S., Aumalikova M.N., Kazymbet P.K., Bakhtin M.M., Dogalbaev Ye.K. Epidemiology of malignant neoplasms among women living in the zone of influence of radioactive waste storage facilities // Nauka i Zdravookhranenie [Science & Healthcare]. 2023, (Vol.25) 4, pp. 101-108. doi 10.34689/SH.2023.25.4.012Related publications:
ANALYSIS OF CLINICAL AND DEMOGRAPHIC INDICATORS OF PATIENTS WITH PARKINSON'S DISEASE IN THE SOUTHERN REGION OF KAZAKHSTAN
A COMPARATIVE STUDY OF DRUG POLICY REGARDING ORPHAN DISEASES IN THE USA, THE EUROPEAN UNION, AND THE REPUBLIC OF KAZAKHSTAN
MUTATIONS IN CARDIAC ION CHANNEL GENES IN KAZAKHSTANI PATIENTS WITH LONG QT SYNDROME
GENETIC FEATURES OF CONGENITAL DYSFUNCTION OF THE ADRENAL CORTEX CAUSED BY 21-HYDROXYLASE DEFICIENCY IN PERSONS OF KAZAKH NATIONALITY
NON-MOTOR SYMPTOMS IN PARKINSON'S DISEASE USING THE EXAMPLE OF AKTOBE PATIENTS