IMMUNOLOGICAL ASPECTS OF THE PATHOGENESIS OF ULCERANT COLITIS
Introduction. The relevance of inflammatory bowel diseases (IBD), which includes ulcerative colitis, is due to the prevalence of the disease among people of working age, chronic relapsing progressive course, and the contribution of an abnormal immune response to the development of destructive inflammation of the intestinal wall. Understanding the immune mechanisms of IBD with the involvement of components of innate and adaptive immunity, including minor lymphocytes in ulcerative colitis, will expand our understanding of their pathogenetic role in the development and maintenance of chronic inflammation.
Materials and methods: The study is observational, analytical, "case control" type, continuous for the study group. The object of the study were patients with inflammatory diseases of the large intestine on the basis of the Department of Proctology and Abdominal Surgery of the East Kazakhstan Regional Medical Association in Ust-Kamenogorsk city.
The immunological parameters with the inclusion of minor lymphocytes were studied. Immunological studies included immunophenotyping of peripheral blood lymphocytes using monoclonal antibodies, determination of the concentration of IgA, IgM, IgG by ELISA, spontaneous and stimulated NST-test
Statistical calculations were carried out using the Statistica5.0 and MicrosoftExcel software packages. The odds of the risk factor in the study groups were also calculated using the new statistical program StatTech h v. 1.2.0 (developer - Stattech LLC, Russia).
The results of the study indicate the involvement in the pathogenesis of ulcerative colitis, along with CD4 + T-lymphocytes, of lymphoid cells with cytotoxic activity, including minor ones: CD8 + T-lymphocytes, T-NK, which have a pro-inflammatory orientation. The mechanisms of damage and maintenance of chronic inflammation in ulcerative colitis also involve nonspecific protection factors of oxidase systems of phagocytic cells with the release of reactive oxygen species (ROS) and pro-inflammatory cytokines of macrophage origin (IL-1β, IL-6, TNF-α).
Conclusions. A comprehensive study of the factors of the immune system in ulcerative colitis will open up prospects for understanding the immunological mechanisms involved in the pathogenesis of chronic inflammation.
Khafiza S. Zhetpisbayeva1, Kapura S. Adrisova2, Bekbolat A. Zhetpisbaev3, Nurzhamal D. Imanbayeva1, Karashash M. Askarova1
1 NJSC "Astana Medical University", Astana Kazakhstan;
2 I Clinic Medical Center, Astana, Kazakhstan;
3 L.N. Gumilyov Eurasian National University, Astana, Kazakhstan.
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Zhetpisbayeva Kh.S., Adrisova K.S., Zhetpisbaev B.A., Imanbayeva N.D., Askarova K.M. Immunological aspects of the pathogenesis of ulcerant colitis // Nauka i Zdravookhranenie [Science & Healthcare]. 2023, (Vol.25) 4, pp. 118-126. doi 10.34689/SH.2023.25.4.014Related publications:
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