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                            CYTOKINE GENE POLYMORPHISM WITH MYOCARDIAL INFARCTION IN SUBJECTS OF RUSSIAN NATIONALITY
                        
            
                
                
                    
            
            
        
                    
                
                Objective: This article considers the study of the frequency of allelic variants and genotypes of cytokines (TNF-α, IL-10, IL-6) in patients of acute myocardial infarction with segment elevation ST (STEMI) in subjects of Russian nationality.
Materials and Methods: The polymorphism of cytokine genes was examined by restriction analysis of specific areas of the genome amplification products in 41 (69.5%) men and 18 (30.5%) women of Russian nationality. Control group was consisted of 75 healthy subjects (donors of Russian nationality). In all ... More
            Materials and Methods: The polymorphism of cytokine genes was examined by restriction analysis of specific areas of the genome amplification products in 41 (69.5%) men and 18 (30.5%) women of Russian nationality. Control group was consisted of 75 healthy subjects (donors of Russian nationality). In all ... More
                                                    2016 year                                                                            | Issue: 5                                                                            | Pages: 121-130                                            
                
                            PARENTS ATTITUDES TO VACCINATION IN SEMEY CITY: A CROSS-SECTIONAL STUDY
                        
            
                
                
                    
            
            
        
                    
                
                Background: The effectiveness of the immunization is proved by international investigations but now many doubts and suspicions of parents toward vaccination exist.
Objectives: To study the attitude of the parents toward vaccination among the population of Semey city.
Methods: the main points of the questionnaire have been developed according to international research data. Answers of the questionnaire were divided into grades: totally agree, rather agree, I have no clear opinion rather disagree, and completely disagree. The frequency and percentages are used to for description of p... More
            Objectives: To study the attitude of the parents toward vaccination among the population of Semey city.
Methods: the main points of the questionnaire have been developed according to international research data. Answers of the questionnaire were divided into grades: totally agree, rather agree, I have no clear opinion rather disagree, and completely disagree. The frequency and percentages are used to for description of p... More
                                                    2016 year                                                                            | Issue: 5                                                                            | Pages: 111-120                                            
                
                            COMBINATIONS OF CONGENITAL HEART DISEASES AND A CONNECTIVE TISSUE DYSPLASIA  AMONG CHILDREN OF SEMEY 
                        
            
                
                
                    
            
            
        
                    
                
                Introduction. There is evidence on common mechanisms of congenital heart diseases (CHD) and connective tissue dysplasia (CTD), which increases odds for their comorbidities. The latter may be associated with poorer prognosis for CHD. However, the associations between CHD and CTD in Kazakhstan have been poorly studied so far. 
Aim – to assess the frequency of CTD signs in children with CHD living in Semey, Kazakhstan.
Materials and methods. We examined 168 children aged 1 to14 years, including 84 – with CHD and 80 children with no signs of CHD.
Associations betw... More
            Aim – to assess the frequency of CTD signs in children with CHD living in Semey, Kazakhstan.
Materials and methods. We examined 168 children aged 1 to14 years, including 84 – with CHD and 80 children with no signs of CHD.
Associations betw... More
                                                    2016 year                                                                            | Issue: 5                                                                            | Pages: 101-110                                            
                
                            CAUSES OF REFUSING MEDICAL EXAMINATIONBY PATIENTS WITH SUSPECTED CANCER AS PERCEIVED BY PRIMARY CARE PHYSICIANS IN SOUTH KAZAKHSTAN REGION
                        
            
                
                
                    
            
            
        
                    
                
                Objective: To identify the most frequent causes of refusing thorough medical examinations by patients with suspected cancer as perceived by primary care physicians in South Kazakhstan Region (SKR).
Methods: We performed a cross-sectional study, which included 500 primary care physicians in SKR. Data collection took place between 01 January 2016 and 14 April 2016). The questionnaire contained 33 semi-open questions. Filling out time was between 20 and 25 minutes. Only doctors who worked at policlinics during the time of the study were included. Results are presented absolute n... More
            Methods: We performed a cross-sectional study, which included 500 primary care physicians in SKR. Data collection took place between 01 January 2016 and 14 April 2016). The questionnaire contained 33 semi-open questions. Filling out time was between 20 and 25 minutes. Only doctors who worked at policlinics during the time of the study were included. Results are presented absolute n... More
                                                    2016 year                                                                            | Issue: 5                                                                            | Pages: 90-100                                            
                
                            IMPACT OF ERYTHROCYTES ANTIGENS ON DEVELOPMENT OF LIVER CIRRHOSIS
                        
            
                
                
                    
            
            
        
    
            
    
                
                Introduction. High rates of prevalence and mortality of liver cirrhosis, it’s late clinical manifestation, disadvantages of liver biopsy highlight the background points of our research. 
Aim. Research of erythrocytes’ antigens profile in patients with liver cirrhosis of Kazakh and Russian ethnical groups.
Materials and Methods: One hundred and forty patients with liver cirrhosis and 272 relatively healthy participants of both of nationalities were involved into research. АВ0, MNS, P1, CDE systems of erythrocytes of venous blood were investigated. For the comparison of the frequenc... More
            Aim. Research of erythrocytes’ antigens profile in patients with liver cirrhosis of Kazakh and Russian ethnical groups.
Materials and Methods: One hundred and forty patients with liver cirrhosis and 272 relatively healthy participants of both of nationalities were involved into research. АВ0, MNS, P1, CDE systems of erythrocytes of venous blood were investigated. For the comparison of the frequenc... More
                                                    2016 year                                                                            | Issue: 5                                                                            | Pages: 80-89                                            
                