POSSIBILITIES OF USING URSODEOXYCHOLIC ACID FOR THE PREVENTION OF ATHEROSCLEROSIS AND LIVER FIBROSIS IN ROUTINE PRACTICE AMONG PATIENTS WITH NON-ALCOHOLIC FATTY LIVER DISEASE
The prevalence of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis (NAFLD/NASH) in the world practice is steadily increasing. NAFLD/NASH can progress to liver cirrhosis and hepatocellular carcinoma. However, most patients with NAFLD/NASH die due to cardiovascular events. It should be noted that the prevalence of NAFLD is increasing parallel to the rising cases of type 2 diabetes (T2D) and obesity. Despite the growing number of patients, therapeutic approaches remain limited. This article presents the results of using ursodeoxycholic acid (UDCA) in NAFLD/NASH. Previously, according to various sources, it was found that bile acids, which include UDCA, are the main integrators of fatty acid and triglyceride metabolism in the liver. The results of our study showed that the use of UDCA in NAFLD leads to a decrease in the activity of inflammatory processes in the liver, its steatosis, and also improves lipid metabolism and has potential anti-atherogenic properties.
Aigul M. Raissova1, Aleksandr V. Nersesov1, Dzhamilya A. Kaibullayeva1, Akzhan U. Konysbekova2, Moldir A. Ismagulova2, Saltanat S. Madenova2, Margarita A. Nefedova3, Madina A. Tatiyeva4, Lyailya K. Tashenova5,
Kulpash S. Kaliaskarova6, Aliya A. Konysbekova7, Shirin B. Aliyeva8,
Guzel M. Dzhakupova9, Yelena I. Lipkina10, Mariya Yu. Nadinskaya11
1 Asfendiyarov National Medical University, Almaty, Republic of Kazakhstan;
2 «National Research Institute of Cardiology and Internal Medicine» JSC, Almaty, Republic of Kazakhstan;
3 INVITRO LLC, Almaty, Republic of Kazakhstan;
4 Central Family Clinic, Almaty, Republic of Kazakhstan;
5 «Institute of Gastroenterology» LLP, Almaty, Republic of Kazakhstan;
6 National Center of Oncology and Transplantology, Astana, Republic of Kazakhstan;
7 Republican Diagnostic Center, Astana, Republic of Kazakhstan;
8 Regional Clinical Hospital, Shymkent, Republic of Kazakhstan;
9 City Advisory Diagnostic Center, Shymkent, Republic of Kazakhstan;
10 Medical Clinic "Belasu", Shymkent, Republic of Kazakhstan;
11 First Moscow State Medical University named after I.M. Sechenov, Ministry of Health of Russia (Sechenov University), Moscow, Russian Federation.
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2. Nersesov A.V., Kaliaskarova K. S., Raisova A.M., Kaibullaeva D.A., Dzhumabaeva A.E., Novitskaya M.S., Zhankalova Z.M. Kharakteristika ambulatornykh patsientov s zabolevaniyami pecheni (khronicheskii virusnyi gepatit, steatoz pecheni, zabolevaniya pecheni, voznikshie na fone sakharnogo diabeta i ozhireniya), poluchayushchikh Essentsiale® forte N v kachestve dopolneniya k standartnoi terapii v usloviyakh real'noi praktiki [Characteristics of outpatients with liver diseases (chronic viral hepatitis, liver steatosis, liver diseases caused by diabetes mellitus and obesity) receiving Essentiale® forte N as an addition to standard therapy in real practice]. Meditsina (Almaty) [Medicine (Almaty)]. 2016. No 9 (171). P. 35–50[in Russian]
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Raisova A.M., Nersesov A.V., Kaibullaeva D.A., Konysbekova A.U., Ismagulova M.A., Madenova S.S., Nefedova M.A., Tatieva M.A., Tashenova L.K., Kaliaskarova K.S., Konysbekova A.A., Alieva Sh.B., Dzhakupova G.M., Lipkina E.I., Nadinskaya M.Yu. Possibilities of using ursodeoxycholic acid for the prevention of atherosclerosis and liver fibrosis in routine practice among patients with non-alcoholic fatty liver disease // Nauka i Zdravookhranenie [Science & Healthcare]. 2023, (Vol.25) 4, pp. 33-41. doi 10.34689/SH.2023.25.4.004Related publications:
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