TRANSORAL LASER SURGERY FOR EARLY LARYNX CANCER
Relevance. Laryngeal cancer occupies one of the leading places in the structure of malignant tumors of the head and neck. Currently, the leading treatment method for early cancer of the vocal fold of the larynx is transoral laser surgery.
Aim. To evaluate the effectiveness of transoral laser surgery for early cancer of the vocal fold of the larynx.
Materials and method. In the period from 2015 to 2020, 18 patients with early cancer of the vocal fold of the larynx were treated using a CO2 laser. All patients had T1 squamous cell carcinoma of the vocal fold of the larynx, of which 16 were stage T1a and 2 were stage T1b. In accordance with the proposal of the European Laryngological Society (ELSOC), transmuscular chordectomy (type III) and total chordectomy (type IV) were performed.
Results. The average length of patient stay in hospital was 2 days. In all cases, a satisfactory functional result was obtained. All operated patients were monitored for at least 3 years. Local relapse was diagnosed in 2 (11.1%) patients. The five-year survival rate was 94.4%.
Conclusions: Transoral laser surgery is an effective treatment for T1c vocal fold cancer of the larynx with satisfactory functional results.
Nargiz V. Kerimova1, https://orcid.org/0009-0008-5081-5618
Аziz A. Aliev1, https://orcid.org/0000-0001-6873-6303
Namik M. Amiraliev1, https://orcid.org/0009-0001-3960-8393
1 Azerbaijan Medical University, Department of Oncology, Baku, Azerbaijan
1. Ambrosch P. The role of laser microsurgery in the treatment of laryngeal cancer // Curr. Opin. Otolaryngol Head Neck Surgery, 2007. 15. 82-88.
2. Ansarin M., Cattaneo A., Benedetto L., Zorzi S., Lombardi F. et. al. Retrospective analysis of factors influencing oncologic outcome in 590 patients with early-intermediate glottic cancer treated by transoral laser microsurgery // Head Neck. 2017. 39. 71-81.
3. Bradley P.J., Mackenzie K., Wight R., Pracy P. et.al. Consensus statement on management in the UK: transoral laser assisted microsurgical resection of early glottic cancer // Clin Otolaryngol. 2009. 135(5). 479-786.
4. Bray F., Ferlay J., Soerjomataran İ. et.al. Global cancer statstis 2018; GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries // Cancer J Clin. 2018. 68. 394-424.
5. Chung Y., Kim K., Keum K., Koh Y. et.al. Radiotherapy versus cordectomy in the management of early glottis cancer. Cancer Res // Treat, 2018. 50(1). 156-163.
6. Feng Y., Wang B., Wen S. Laser surgery versus radiotherapy for T1-T2N0 glottic cancer: a metanalysis // Otorhinolaryngology, 2011. 73; 336-342.
7. Harti D., Ferlito A., Brasnu D., Langendijk J. et.al. Evidence-based review of treatment optiona for patienta with glottic cancer // Head Neck, 2011. 3; 1638-1648
8. Honocodeevar – Boltezar I., Zargi M. Voice quality after radiation therapy for early glottis cancer // Arch. Otolaryngol Head Neck Surg., 2000. 126. 1097-1100.
9. Karatzanis A., Psychogios G., Zenk J., Waldfahrer F. et.al. Comrasioc among different available surgical approaches in T1 glottic cancer // Laryngoscope, 2009. 119. 1704-1708.
10. Landotto V., Gervasio C., Riva G., Garzaro M. et.al. Prognostic role of margin status in open and CO2 laser cordectomy for T1a-T1b glottiс cancer // Braz J. Otorhinolaryngol, 2016. 84(1), 74-81.
11. Marshak G., Brenner B., Shvero J. et.al. Prognostic factors for local control of early glottis cancer: the Rubin Medical Center retrospective study on 207 patients // Int. J. Radiat. Oncol. Biol. Phys. 1999. 43. 1009-1013.
12. Mendenhall W., Werning J., Hinerman R., Amdur R., Villaret D. Management of T1-T2 glottic carcinomas // Cancer, 2004. 100(9). 1786-1792.
13. National Comprehensive Cancer Network (NCCN) (2018). Head and neck cancer guidelines // TNM Staging. 123-125.
14. Nozaki M., Furuta M., Murakami Y. et.al. Radiation therapy for T1 glottic cancer: involvement of the anterior commissure // Auticancer Res. 2000. 20. 1121-1124.
15. Reddy S., Mohideen N., Marra S., Mark J. Effect of tumor bulk on local control and survival of patients with T1 glottic cancer // Radiother Oncol., 1998. 47. 161-166.
16. Remacle M., Van Haverbeke C., Eckel H. et.al. Propasal for revision of the European Laryngological Society classification of endoscopic cordectomies // Eur. Arch. Otorhinolaryngol, 2007. 264(5). 499-504.
17. Stoeckli S., Schnieper İ., Huguenin P., Schmid S. Early glottic carcinoma: treatment accordind patients preference // Head and Neck, 2003. 25(12). p051-1056.
18. Steiner W., Ambrosch P. Advantages of transoral laser microsurgery over standart therapy. İn: Endoscopic laser surgery of the upper aerodigestive tract // Stutgart: Georg Thieme Verlag. 2000. 44-45.
19. Strong M.S., Jako G.J. Laser surgery in the larynx. Early clinical experience with continuous CO2 laser // Ann. Otol. Prhinol. Laryngol, 1972. 81(6). 791-798.
20. Strong M.S. Laser excision of carcinoma of the larynx. Laryngoscope, 1975; 85(8); 1286-1289
21. Stener C.E., El-Deiry M. Parks J.R. et.al. An updat on larynx cancer // CA Cancer J. Clin. 2017. 67. 31-50.
Number of Views: 48
Category of articles:
Original articles
Bibliography link
Kerimova N.V., Aliev А.A., Amiraliev N.M. Transoral laser surgery for early larynx cancer // Nauka i Zdravookhranenie [Science & Healthcare]. 2023, (Vol.25) 5, pp. 78-82. doi 10.34689/SH.2023.25.5.010Related publications:
ANALYSIS OF CLINICAL AND DEMOGRAPHIC INDICATORS OF PATIENTS WITH PARKINSON'S DISEASE IN THE SOUTHERN REGION OF KAZAKHSTAN
A COMPARATIVE STUDY OF DRUG POLICY REGARDING ORPHAN DISEASES IN THE USA, THE EUROPEAN UNION, AND THE REPUBLIC OF KAZAKHSTAN
MUTATIONS IN CARDIAC ION CHANNEL GENES IN KAZAKHSTANI PATIENTS WITH LONG QT SYNDROME
GENETIC FEATURES OF CONGENITAL DYSFUNCTION OF THE ADRENAL CORTEX CAUSED BY 21-HYDROXYLASE DEFICIENCY IN PERSONS OF KAZAKH NATIONALITY
NON-MOTOR SYMPTOMS IN PARKINSON'S DISEASE USING THE EXAMPLE OF AKTOBE PATIENTS