ESTABLISHING A FAMILIAL HYPERCHOLESTEROLAEMIA REGISTER IN THE REPUBLIC KAZAKHSTAN
Background: Familial hypercholesterolemia (FH) is a prevalent genetic disorder that impacts cholesterol metabolism and low-density lipoprotein (LDL-C) levels. In the absence of treatment, elevated LDL-C levels can precipitate the early onset of atherosclerosis, significantly heightening the risk of premature cardiovascular diseases.
Aim of the Study: The primary objective of this study is to develop and implement a national registry for individuals diagnosed with familial hypercholesterolemia (FH). This registry aims to facilitate systematic monitoring, effective treatment, and the prevention of cardiovascular complications, including heart attacks and strokes. Furthermore, it seeks to explore correlations between patients' age and gender with FH, identify genetic factors, ascertain their prevalence within the study cohort, and subsequently apply the findings on a national scale, integrating them into healthcare practices.
Materials and Methods: The study design was formulated in accordance with the International Registry of Familial Hypercholesterolemia (FH).
Conclusion: The established national registry will be seamlessly integrated into the global registry system for patients with familial hypercholesterolemia (FH). This integration will enhance transparency and global awareness of the prevalence of FH in Kazakhstan. The creation and implementation of this registry will make substantial contributions to enhancing the quality of healthcare and mitigating the risk of cardiovascular complications among FH patients within the country.
Кairat К. Davletov1, https://orcid.org/0000-0001-8534-1899
Alexander R.M. Lyons2, https://orcid.org/0000-0001-5023-8824
Natalya E. Glushkova1, https://orcid.org/0000-0003-1400-8436
Mukhtar B. Kulimbet1, https://orcid.org/0000-0003-4399-700X
Kulman S. Nyssanbaeva1, https://orcid.org/0000-0003-1239-8610
Akbope K. Myrkassymova1, https://orcid.org/0000-0002-2134-2494
Timur M. Saliev1, https://orcid.org/0000-0001-5696-6363
Ildar R. Fakhradiyev1, https://orcid.org/0000-0003-0528-3874
1 Asfendiyarov Kazakh National Medical University, Almaty c., Republic of Kazakhstan;
2 Imperial College London, London, United Kingdom.
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Davletov К.К., Lyons A.R.M., Glushkova N.E., Kulimbet M.B., Kulman S., Nyssanbaeva K., Myrkassymova A.K., Saliev T.M., Fakhradiyev I.R. Establishing a familial hypercholesterolaemia register in the Republic Kazakhstan // Nauka i Zdravookhranenie [Science & Healthcare]. 2023, (Vol.25) 6, pp. 128-132. doi 10.34689/SH.2023.25.6.015Related publications:
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