KIDNEY CANCER IN EAST KAZAKHSTAN REGION: COMPONENT ANALYSIS OF INCIDENCE (2010-2019)
Introduction. In the world, about 430 thousand new cases of kidney cancer (KC) are diagnosed every year. KC is one of the most important types of cancer, partly because it continues to impose a significant economic burden on the health care system. The study of the incidence of KC has great scientific and practical significance in terms of identifying risk factors, monitoring and evaluating preventive measures and developing new methods of diagnosis and treatment.
The aim of the study is to evaluate the incidence of KC in East Kazakhstan region using component analysis.
Material and research methods. In a retrospective study of the data of the Ministry of Health of the Republic of Kazakhstan on new cases of KC in the East Kazakhstan region, obtained from Form No.7, descriptive and analytical methods of epidemiology were used. To analyze the dynamics of incidence based on the number of cases from 2010 to 2019, a component analysis was used.
Results. During the study period (2010-2019), 1,279 new cases of KC were registered in the East Kazakhstan region. The average annual incidence of KC in East Kazakhstan region was 9.2±0.4 (95%CI=8.4-10.1) per 100,000 population. The overall increase in incidence in the male population was +5.740/0000, and in the female population +3.210/0000. The incidence of KC in both sexes is increasing. The overall increase was +4.420/0000 and depended on changes in the age structure of the population (∑ΔA=+1.110/0000), the risk of getting sick (∑ΔR=+3.130/0000) and the cumulative effect of the age structure and the risk of getting sick (∑ΔAR=+0.180/0000). According to the calculations of the component analysis, 118 patients were expected in 2019. Instead, the number of patients increased to 163. Thus, KC is characterized by an increase in cases, mainly due to a change in the risk of getting sick (+42.0% of the total increase by +56.7%).
Conclusions. Our study shows that the increase in the number of patients is associated with risk factors, with changes in the age structure of the population of the region, which are associated with a change in the age type of the population towards regressive. Improved health policy and awareness of disease prevention can play an important role in reducing the burden of cancer.
Nurbek S. Igissin1,2,3, https://orcid.org/0000-0002-2517-6315
Sergey S. Dyakov4,2,5, https://orcid.org/0000-0001-7566-7094
Zhansaya B. Telmanova2, https://orcid.org/0000-0002-2364-6520
Indira O. Kudaibergenova5,3, https://orcid.org/0000-0003-3007-8127
Zaituna G. Khamidullina6, https://orcid.org/0000-0002-5324-8486
Akzhunis M. Jexenova6, https://orcid.org/0000-0001-9771-0882
Zhanerke R. Azhetova6,2, https://orcid.org/0000-0002-8266-1720
Serikbay T. Orozbaev6,2, https://orcid.org/0000-0003-3895-0426
Gulnur S. Igissinova7,2, https://orcid.org/0000-0001-6881-2257
Zarina A. Bilyalova2,3, https://orcid.org/0000-0002-0066-235X
Saken K. Kozhakhmetov6, https://orcid.org/0000-0002-0075-0376
1 Research Institute of Life and Health Sciences, Higher School of Medicine, Kokshetau University named after Sh. Ualikhanov, Kokshetau, Kazakhstan;
2 Central Asian Institute for Medical Research, Astana, the Republic of Kazakhstan;
3 Asian Pacific Organization for Cancer Prevention, Bishkek, the Kyrgyz Republic;
4 National Scientific Center of Traumatology and Orthopedics named after Academician Batpenov N.D. of the Ministry of Health of the Republic of Kazakhstan, Astana, the Republic of Kazakhstan;
5 Akhunbaev Kyrgyz State Medical Academy, Bishkek, the Kyrgyz Republic;
6 NCJSC «Astana Medical University», Astana, the Republic of Kazakhstan;
7 NCJSC «Asfendiyarov Kazakh National Medical University», Almaty, the Republic of Kazakhstan.
1. Бюро национальной статистики Агентства стратегического планирования и реформ Республики Казахстан. https://stat.gov.kz (Дата обращения 01.05.2023).
2. Гланц С. Медико-биологическая статистика. Москва: Практика, 1999, 460 с.
3. Двойрин В.В., Аксель Е.М. Компонентный анализ динамики заболеваемости злокачественными новообразованиями (методические рекомендации). Москва, 1987, 10 с.
4. Дьяков С.С., Тельманова Ж.Б., Билялова З.А., Ажетова Ж.Р., и др. Оценка изменений показателей онкологической помощи при раке почки в Казахстане // Онкология и радиология Казахстана. 2022. 4(66), С. 4–9.
5. Игисинов Н.С., Балтакаева А.М. Пространственная оценка заболеваемости ожирением в Казахстане // Молодой ученый. 2011. 2(25), С. 153-156.
6. Мерков А.М., Поляков Л.Е. Санитарная статистика. Ленинград: Медицина, 1974, 384 с.
7. Bahadoram S., Davoodi M., Hassanzadeh S., Bahadoram M. et al. Renal cell carcinoma: an overview of the epidemiology, diagnosis, and treatment // G Ital Nefrol. 2022. 39(3), P. 2022-vol3.
8. Capitanio U., Bensalah K., Bex A., et al. Epidemiology of Renal Cell Carcinoma // Eur Urol. 2019. 75(1), P. 74-84.
9. Capitanio U., Montorsi F. Renal cancer // Lancet. 2016. 387, P. 894–906.
10. Chien C.R., Geynisman D.M., Kim B. et al. Economic Burden of Renal Cell Carcinoma—Part I: An Updated Review // Pharmaco Economics. 2019. 37, P. 301–331.
11. Chow W-H., Dong L.M., Devesa S.S. Epidemiology and risk factors for kidney cancer // Nat. Rev. Urol. 2010. 7, P. 245–257.
12. GBD 2015 Tobacco Collaborators. Smoking prevalence and attributable disease burden in 195 countries and territories, 1990-2015: a systematic analysis from the Global Burden of Disease Study 2015 // Lancet. 2017. 389(10082), P. 1885-1906.
13. GBD 2019 Demographics Collaborators. Global age-sex-specific fertility, mortality, healthy life expectancy (HALE), and population estimates in 204 countries and territories, 1950-2019: a comprehensive demographic analysis for the Global Burden of Disease Study 2019 // Lancet. 2020. 396(10258), P. 1160-1203.
14. Ferlay J., Ervik M., Lam F. et al. Global Cancer Observatory: Cancer Today. Lyon, France: International Agency for Research on Cancer. 2020. https://gco.iarc.fr/today (Дата обращения 02.05.2023).
15. Harrison H., Thompson R.E., Lin Z., et al. Risk Prediction Models for Kidney Cancer: A Systematic Review // Eur Urol Focus. 2021. 7(6), P. 1380-1390.
16. Maher E.R. Hereditary renal cell carcinoma syndromes: diagnosis, surveillance and management // World J Urol. 2018. 36, P. 1891–1898.
17. Nam G.E., Cho K.H., Han K., Kim CM, et al. Obesity, abdominal obesity and subsequent risk of kidney cancer: a cohort study of 23.3 million East Asians // Br J Cancer. 2019. 121, P. 271–7.
18. National Cancer Institute at the National Institutes of Health. Advances in Kidney Cancer Research. https://www.cancer.gov/types/kidney/research (Дата обращения 04.05.2023)
19. National Kidney Foundation, 2023. https://www.kidney.org/atoz/content/about-chronic-kidney-disease research (Дата обращения 04.05.2023)
20. Rossi S.H., Klatte T., Usher-Smith J., Stewart G.D. Epidemiology and screening for renal cancer // World J Urol. 2018. 36, P. 1341–1353.
21. Rossi S.H., Klatte T., Usher-Smith J.A., et al. A decision analysis evaluating screening for kidney cancer using focused renal ultrasound // Eur Urol Focus. 2021. 7(2), P. 407-419.
22. Rossi S.H., Klatte T., Stewart G.D. Quality of life outcomes in patients with localised renal cancer: a literature review // World J Urol. 2018. 36(12), P. 1961-1972.
23. Safiri S., Kolahi A.A., Mansournia M.A., et al. The burden of kidney cancer and its attributable risk factors in 195 countries and territories, 1990-2017 // Sci Rep. 2020. 10(1), P. 13862.
24. Scelo G., Larose T.L. Epidemiology and risk factors for kidney cancer // J. Clin. Oncol. 2018. 36, P. 3574.
25. Shen T., Shu X.O., Xiang Y.B., et al. Association of hypertension and obesity with renal cell carcinoma risk: a report from the Shanghai Men's and Women's Health Studies // Cancer Causes Control. 2015. 26(8), P. 1173-1180.
26. Tahbaz R., Schmid M., Merseburger A.S. Prevention of kidney cancer incidence and recurrence: lifestyle, medication and nutrition // Curr Opin Urol. 2018. 28(1), P. 62-79.
27. Tian Y.Q., Yang J.C., Hu J.J., Ding R., Ye D.W., Shang J.W. Trends and risk factors of global incidence, mortality, and disability of genitourinary cancers from 1990 to 2019: Systematic analysis for the Global Burden of Disease Study 2019 // Front Public Health. 2023. 11, P. 1119374.
28. Washio M., Mori M., Mikami K., Miki T., et al. Cigarette smoking and other risk factors for kidney cancer death in a Japanese population: Japan collaborative cohort study for evaluation of cancer risk (JACC study) // Asian Pac J Cancer Prev. 2014. 14, P. 6523–8.
29. Zi H., He S.H., Leng X.Y., et al. Global, regional, and national burden of kidney, bladder, and prostate cancers and their attributable risk factors, 1990-2019 // Mil Med Res. 2021. 8(1), P. 60.
References: [1-6]
1. Byuro nacional'noj statistiki Agentstva po strategicheskomu planirovaniyu i reformam Respubliki Kazahstan [The Bureau of National Statistics of the Agency for Strategic Planning and Reforms of the Republic of Kazakhstan]. Available from: https://stat.gov.kz/ (Accessed 01.05.2023).
2. Glanc S. Mediko-biologicheskaya statistika [Biomedical statistics]. Moscow, Praktika [Practice], 1999, 460 p. [in Russian]
3. Dvoyrin V.V., Aksel E.M. Komponentnyi analiz dinamiki zabolevaemosti zlokachestvennymi novoobrazovaniyami (metodicheskie rekomendatsii) [Component analysis of the dynamics of the incidence of malignant neoplasms (methodological recommendations)]. Moscow, 1987. 10 p. [in Russian]
4. Dyakov S.S., Telmanova Zh.B., Bilyalova Z.A., Azhetova Zh.R., et al. Otsenka izmenenii pokazatelei onkologicheskoi pomoshchi pri rake pochki v Kazakhstane [Assessment of changes in indicators of oncological care for kidney cancer in Kazakhstan]. Onkologiya i radiologiya Kazakhstana [Oncology and radiology of Kazakhstan]. 2022. 4(66), P. 4-9.
5. Igissinov N., Baltakaeva A. Prostranstvennaya otsenka zabolevaemosti ozhireniem v Kazakhstane [Spatial assessment of the incidence of obesity in Kazakhstan]. Molodoi uchenyi [Young scientist]. 2011. 2(25), P. 153-156. [in Russian]
6. Merkov A.M., Polyakov L.E. Sanitarnaya statistika [Sanitary statistics]. Leningrad, Meditsina [Medicine], 1974, 384 p. [in Russian]
Number of Views: 65
Category of articles:
Original articles
Bibliography link
Igissin N.S., Dyakov S.S., Telmanova Zh.B., Kudaibergenova I.O., Khamidullina Z.G., Jexenova A.M., Azhetova Zh.R., Orozbaev S.T., Igissinova G.S., Bilyalova Z.A., Kozhakhmetov S.K. Kidney cancer in East Kazakhstan region: component analysis of incidence (2010-2019) // Nauka i Zdravookhranenie [Science & Healthcare]. 2023, (Vol.25) 6, pp. 22-29. doi 10.34689/SH.2023.25.6.003Related publications:
ANALYSIS OF CLINICAL AND DEMOGRAPHIC INDICATORS OF PATIENTS WITH PARKINSON'S DISEASE IN THE SOUTHERN REGION OF KAZAKHSTAN
A COMPARATIVE STUDY OF DRUG POLICY REGARDING ORPHAN DISEASES IN THE USA, THE EUROPEAN UNION, AND THE REPUBLIC OF KAZAKHSTAN
MUTATIONS IN CARDIAC ION CHANNEL GENES IN KAZAKHSTANI PATIENTS WITH LONG QT SYNDROME
GENETIC FEATURES OF CONGENITAL DYSFUNCTION OF THE ADRENAL CORTEX CAUSED BY 21-HYDROXYLASE DEFICIENCY IN PERSONS OF KAZAKH NATIONALITY
NON-MOTOR SYMPTOMS IN PARKINSON'S DISEASE USING THE EXAMPLE OF AKTOBE PATIENTS