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IMMUNOHISTOCHEMICAL ANALYSIS EXPRESSION TP73 IN ONCOCYTIC FOLLICULAR ADENOMA OF THE THYROID
Oncocytic follicular adenomas (FAs) of the thyroid are cells neoplasms of follicular origin that predominantly consist of large polygonal cells with eosinophilic and granular cytoplasm. According to some scientific studies, TP73 might play a сertain role in tumor genesis (oncogenesis). Moreover, due to the absence of p53, oncogenes may attract p73 to induce apoptosis in tumor cells. TP53 is a crucial tumor suppressor in preventing the cancerous transformation of cells. There was also a particular focus on the amplification of 1p36 chromosome in oncocytic FA, which contains a t...
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2017 year | Issue: 1 | Pages: 64-73
ASSESSMENT OF TOXICITY OF NEOADJUVANT CHEMOTHERAPY FOR LOCALLY ADVANCED BREAST CANCER
Introduction. In the structure of malignancies in women breast cancer (BC) takes 1st place. In locally advanced breast cancer (LABC) treatment begins with neoadjuvant chemotherapy (CTX), the standard protocols are CMF, FAC, AC. In the trial, we used cytostatic Arglabin isolated from plants endemic to Central Kazakhstan - wormwood smooth, as monotherapy and as addition to AC-protocol.
The objective of the trial - to assess the toxicity of different protocols of neoadjuvant CTX of LABC.
Methods: 93 patients with LABC (T2N1-2M0, T3N0-2M0) ... More
The objective of the trial - to assess the toxicity of different protocols of neoadjuvant CTX of LABC.
Methods: 93 patients with LABC (T2N1-2M0, T3N0-2M0) ... More
2017 year | Issue: 1 | Pages: 52-63
CLINICAL EVALUATION OF THE EFFICIENCY OF ORTHOPEDIC TREATMENT OF PATIENTS WITH EDENTULOUS JAWS WITH COMPLETE REMOVABLE DENTURES USING C-SILICONE MATERIALS FOR FUNCTIONAL IMPRESSIONS
Introduction. Prosthetics of edentulous jaw is one of the most difficult sections of prosthetic dentistry for many years. The difficulty lies in the production of functionally effective complete dentures that are in direct proportion to their fixation on the jaws, stabilization during chewing and even distribution of pressure on the underlying tissues.
The aim of this research was to conduct a comparative clinical evaluation of the efficiency of the complete removable laminar dentures that were made with use of the new materials for functional impressions.
Methods. At... More
The aim of this research was to conduct a comparative clinical evaluation of the efficiency of the complete removable laminar dentures that were made with use of the new materials for functional impressions.
Methods. At... More
2017 year | Issue: 1 | Pages: 37-51
MANAGEMENT MODEL BY MEDICAL PERSONNEL’S MOTIVATION ON THE EXAMPLE OF THE REGIONAL ONCOLOGY CENTER OF SEMEY
The paper presents a model of motivational management by medical staff of Regional oncology center of Semey city, on the basis of which is situated the chair of oncology and radiology named after D.R. Mussinov, MD, professor. At the chair are trained on the residency program, magistracy, Ph doctoral program. Staff motivation is set out in the form of implementation of the Program development of oncological cancer care in 2012-2015 years, including the development of nuclear medicine. Creation of highly efficient and motivated teams, including in health care institutions, will increase labor pr...
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2015 year | Issue: 1 | Pages: 70-76
CONDITION OF COAGULATION HEMOSTASIS AMONG WOMEN, WHO ARE IN THE RISK GROUP BY POSTPARTUM HAEMORRHAGE DEPENDING ON CHILDBIRTHS PARITY
Background: Obstetric haemorrhage is the important issue of obstetrics and one of the major causes of maternal mortality and morbidity in the world. Multiparous women take up a large proportion among dead women. More than 2/3 of blood loss, including threatening the mother’s life, is associated with disorders of hemostasis.
The aim: to evaluate the coagulation system in women with risk factors for postpartum haemorrhage depending on childbirths parity.
Methods: 126 pregnant women were examined, i.e. 96 pregnant women of haemorrhage risk group and 30 pregnant women with physiologic ... More
The aim: to evaluate the coagulation system in women with risk factors for postpartum haemorrhage depending on childbirths parity.
Methods: 126 pregnant women were examined, i.e. 96 pregnant women of haemorrhage risk group and 30 pregnant women with physiologic ... More
2015 year | Issue: 1 | Pages: 60-69