INFLUENCE OF CLONAL HAEMATOPOIESIS OF INDETERMINATE POTENTIAL (CHIP) ON THE DEVELOPMENT OF ATHEROSCLEROSIS
: Recent studies in single-cell RNA sequencing have improved the understanding of the structure of immune cell subpopulations in atherosclerosis. With the help of new technologies, new subpopulations of immune cells involved in atherosclerosis have been identified. Additionally, a relatively common and strong cardiovascular risk factor has emerged: clonal hematopoiesis of indeterminate potential (CHIP). This process occurs due to an increase in the concentration of somatic mutations over a lifetime and the formation of mutant clones of circulating leukocytes. Individuals with CHIP have a high risk of developing cardiovascular diseases, such as myocardial infarction and stroke, regardless of traditional risk factors.
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Bekbosynova M.S., Andosova S.A., Rysbekova A.S., Daniyarova G.D. Influence of clonal haematopoiesis of indeterminate potential (CHIP) on the development of atherosclerosis // Nauka i Zdravookhranenie [Science & Healthcare]. 2024. Vol.26 (4), pp. 202-210. doi 10.34689/SH.2024.26.4.023Related publications:
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