POLYMORPHISM OF IL10 GENE AT -1082G/A POSITION IN PATIENTS WITH ERYSIPELAS
The aim of this study is reveal the association of polymorphism of IL10 gene (rs1800896) at 1082 GA position with the erysipelas in Kazakh population.
Materials and methods. The polymorphism of IL10 gene (rs1800896) was assessed in 206 patients with erysipelas and 422 control subjects. Of them 143 patients with primary erysipelas and 63 with recurrence erysipelas. Genomic DNA was extracted from blood for genotyping. Genotyping of polymorphism of IL10 gene (-1082 GA) was conducted by method of polymerase chain reaction in real time. Pearson’s Chi tests and odds ratios (OR) with 95 % confidence intervals (CI) were using for statistical analysis.
Our results showed that G allele and GG genotype more common in both group: in patients and in control group (OR = 0.87; 95% CI: 0.68–1.12 and OR = 0.86; 95% CI: 0.61–1.19, respectively). Also statistical significant differences by the frequency of occurrence of allele A (OR = 1.14; 95% CI: 0.89–1.47) and AA (OR = 1.20; 95% CI: 0.73–2.00) genotype in patients with the control group are not revealed. When comparing patients with primary erysipelas (case group) and control group, and patients with recurrent erysipelas (case group) with a individuals of control group were also observed no statistically significant results.
Conclusions. So, our results suggested that no association of polymorphism of IL10 gene (rs1800896) at position -1082 GA with erysipelas in Kazakh population.
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Бекенова Н.Б., Гржибовский А.М., Муковозова Л.А., Аукенов Н.Е. Полиморфизм гена ИЛ10 в положении -1082G/A у больных рожей / / Наука и Здравоохранение. 2016. №3. С. 34-45. Bekenova N.B., Grjibovski A.M., Mukovozova L.A., Aukenov N.Ye. Polymorphism of IL10 gene at -1082G/A position in patients with erysipelas. Nauka i Zdravookhranenie [Science & Healthcare]. 2016, 3, pp. 34-45. Бекенова Н.Б., Гржибовский А.М., Муковозова Л.А., Аукенов Н.Е. Тілмемен ауыратын науқастарда ИЛ10 генінің полиморфизмі (-1082G/A) / / Ғылым және Денсаулық сақтау. 2016. №3. Б. 34-45.Related publications:
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