CYTOKINE GENE POLYMORPHISM WITH MYOCARDIAL INFARCTION IN SUBJECTS OF RUSSIAN NATIONALITY
Objective: This article considers the study of the frequency of allelic variants and genotypes of cytokines (TNF-α, IL-10, IL-6) in patients of acute myocardial infarction with segment elevation ST (STEMI) in subjects of Russian nationality.
Materials and Methods: The polymorphism of cytokine genes was examined by restriction analysis of specific areas of the genome amplification products in 41 (69.5%) men and 18 (30.5%) women of Russian nationality. Control group was consisted of 75 healthy subjects (donors of Russian nationality). In all subjects were studied single nucleotide polymorphism SNP-gene promoter region TNF-α (G-308A), IL-10 (G-1082A), IL-6 (G-174C). STEMI diagnosis was for accordance with the classification of the European Society of Cardiology (ESC). All patients were divided into 2 groups, where the group of uncomplicated STEMI amounted to 34 (57.6%) patients who did not have complications, both in hospital period and posthospital period. The second group was consisted of 25 (42.4%) patients with complicated course of STEMI.
Results: In this paper shows, the association of the homozygous genotype minor type A / A in the position of G-308A promoter region of the TNFα gene with complicated STEMI (OR = 6,72, p<0.05). It was revealed that the minor type homozygous genotype C / C position of G-174C promoter region of the gene IL-6 is also associated with complicated STEMI (OR = 3,25, p<0.05). According to our results, there were no significant differences in the frequency of alleles and genotypes of polymorphism G-1082A gene IL-10, depending on the course of STEMI. Thus, polymorphisms of cytokine genes could be considered as a possible genetic risk factor for morbidity in patients with STEMI of Russian nationality (East Kazakhstan region of the Republic of Kazakhstan), after further study, with a significant increase the size of sample.
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Аймагамбетова А.О., Каражанова Л.К., Котляр А., Токбулатова М.О. Полиморфизм генов цитокинов при инфаркте миокарда у лиц русской национальности / / Наука и Здравоохранение. 2016. № 5. С. 121-130. Aimagambetova A.О., Karazhanova L.K., Kotlyar A., Tokbulatova M.O. Cytokine gene polymorphism with myocardial infarction in subjects of russian nationality. Nauka i Zdravookhranenie [Science & Healthcare]. 2016, 5, pp. 121-130. Аймагамбетова А.О., Каражанова Л.К., Котляр А., Токбулатова М.О. Ұлты орыс науқастарының миокард инфаркты кезіндегі цитокиндер генінің полиморфизмы / / Ғылым және Денсаулық сақтау. 2016. № 5. Б. 121-130Related publications:
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