FEATURES OF IMMUNE RESPONSE IN NEWBORN CHILDREN WITH LOW BODY WEIGHT IN INTRAUTERINE INFECTION
Introduction. Intrauterine infections are considered to be of central significance among the problems of the field of perinatal medicine. In the circumstances where an organism gets infected, the components of the monocyte-macrophage system begin to produce pro- and anti-inflammatory cytokines.
Objective. Perform and compare the level and proportion between the pro- and anti-inflammatory cytokines among newborn children suffering intrauterine infection, depending on the weight of the body.
Results. In case of newborn children weighted 2500g., there have been higher levels of pro-inflammatory cytokines in the serum, IL-1β, as compared to similar parameters among newborn children with a low body weight at the time of birth (p<0.001). The lower contents of IL-1β in the serum of immature babies may be accounted for by considering the immaturity and the low functional activity of the immune cells that synthesize pro-inflammatory cytokines. Levels of anti-inflammatory IL-10 cytokine are also higher among mature newborn children in comparison to the ones with a low body weight at the time of birth (р = 0.002).
Conclusions. Level of pro- and anti-inflammatory cytokines for newborn children with a low body weight is assuredly low, as compared to the similar cytokine in mature newborns. Among newborn children with a low body weight, immune response to the infection process is significantly reduced, as compared to mature newborn children, which may be accounted for by the immaturity of the cell-humoral component of their immune systems.
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Tussupkaliev B. T., Zhumalina A. K., Zhekeyeva B. A., Baizhanova R. M. Features of immune response in newborn children with low body weight in intrauterine infection. Nauka i Zdravoohranenie [Science & Healthcare]. 2015, 5, pp. 52-60.Related publications:
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