ASSESSMENT OF IMPACT OF GENE POLYMORPHISM IL-10 ON OUTCOMES OF CHRONIC VIRAL HEPATITIS IN KAZAKH POPULATION: CASE-CONTROL STUDY
Purpose of the study is analysis of the polymorphism of cytokine gene IL10 (rs1800872) in patients of Kazakh population with chronic viral hepatitis to assess the risk of liver cirrhosis.
Materials and methods. In total, 652 people were studied. There were 90 patients with liver cirrhosis of viral etiology (LC), 296 people with chronic viral hepatitis (CVH) B and / or C and 266 donors of control group (absence of liver disease in anamnesis, HBV and HCV-negative). Polymorphism of IL10 (rs1800872) were genotyped by Real-time PCR.
Results. The frequency of allele A is significantly higher in patients with liver cirrhosis (OR = 1,56, 95% CI 1,11 – 2,19, p=0,01) and chronic viral hepatitis (OR = 1,44, 95% CI 1,14 -1,82, p=0,002) in comparison with control group. The incidence of genotype AA and AC is also significantly higher in patients with liver cirrhosis (OR = 2,38, 95% CI 1,27 – 4,45, p=0,006) and chronic viral hepatitis (OR = 2,10, 95% CI 1,41 -3,13, p <0,001) compared with control. Thus, the allele A and genotype AA and AC are associated with the development of chronic viral liver diseases in Kazakh population.
Conclusion. The study shows that IL-10 gene polymorphism rs1800872 plays an important role in the risk of developing of liver cirrhosis and chronic viral hepatitis in Kazakh population.
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Massabayeva M. R., Aukenov N. E., Babenko D. B., Azizov I. S., Maukayeva S. B., Tokayeva A. Z., Khamitova M. O. Assessment of impact of gene polymorphism IL-10 on outcomes of chronic viral hepatitis in kazakh population: case-control study. Nauka i Zdravoohranenie [Science & Healthcare]. 2015, 6, pp. 67-76.Related publications:
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